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46393

Fluo-3

Name: Fluo-3
Brand: SIGMA

suitable for fluorescence, ~70%

别名:

4-(2,7-二氯-6-羟基-3-氧代-9-二苯基)-4′-甲基-2,2′-(亚乙二氧基)二苯胺-N,N,N′,N′-四乙酸

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关于此项目

经验公式（希尔记法）:

C₃₆H₃₀Cl₂N₂O₁₃

化学文摘社编号:

123632-39-3

分子量:

769.54

NACRES:

NA.32

PubChem Substance ID:

329757162

UNSPSC Code:

12352106

MDL number:

MFCD00083337

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属性

assay

~70%

Quality Level

100

form

solid

solubility

H₂O: soluble

fluorescence

λ_ex 506 nm; λ_em 526 nm in 0.1 M Tris pH 8.0, esterase 30 mM Ca²⁺

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

Cc1ccc(N(CC(O)=O)CC(O)=O)c(OCCOc2cc(ccc2N(CC(O)=O)CC(O)=O)C3=C4C=C(Cl)C(=O)C=C4Oc5cc(O)c(Cl)cc35)c1

InChI

1S/C36H30Cl2N2O13/c1-18-2-4-24(39(14-32(43)44)15-33(45)46)30(8-18)51-6-7-52-31-9-19(3-5-25(31)40(16-34(47)48)17-35(49)50)36-20-10-22(37)26(41)12-28(20)53-29-13-27(42)23(38)11-21(29)36/h2-5,8-13,41H,6-7,14-17H2,1H3,(H,43,44)(H,45,46)(H,47,48)(H,49,50)

InChI key

OZLGRUXZXMRXGP-UHFFFAOYSA-N

说明

Application

Fluo-3和相关分子Fluo3/AM可用作细胞内钙离子（Ca2+）的荧光指示剂。Fluo-3可用于流式细胞术以及使用可见光激发的共焦激光扫描显微术（与在488nm下操作的氩激光源兼容）。与钙结合后，荧光强度增加约40倍。

Other Notes

用于流式细胞术的钙离子荧光指示剂。与钙结合后，荧光强度增加约40倍

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

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Flow cytometric measurement of cytoplasmic free calcium in human peripheral blood T lymphocytes with fluo-3, a new fluorescent calcium indicator.

P A Vandenberghe et al.

Journal of immunological methods, 127(2), 197-205 (1990-03-09)

Cytoplasmic free calcium [( Ca2+]i) is a key intracellular messenger in many cell types. We have used fluo-3, a recently developed calcium probe, to study [Ca2+]i in resting and stimulated human peripheral blood T lymphocytes. The spectral properties of fluo-3

In vitro and in vivo effects of kisspeptin antagonists p234, p271, p354, and p356 on GPR54 activation.

C H J Albers-Wolthers et al.

PloS one, 12(6), e0179156-e0179156 (2017-06-27)

Kisspeptins (KPs) and their receptor (GPR54 or KiSS1R) play a key-role in regulation of the hypothalamic-pituitary-gonadal axis and are therefore interesting targets for therapeutic interventions in the field of reproductive endocrinology. As dogs show a rapid and robust LH response

A Sustained Activation of Pancreatic NMDARs Is a Novel Factor of β-Cell Apoptosis and Dysfunction.

Xiao-Ting Huang et al.

Endocrinology, 158(11), 3900-3913 (2017-09-25)

Type 2 diabetes, which features β-cell failure, is caused by the decrease of β-cell mass and insulin secretory function. Current treatments fail to halt the decrease of functional β-cell mass. Strategies to prevent β-cell apoptosis and dysfunction are highly desirable.

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46393-5MG-F	04061833277256
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