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安全信息

462R-1

Sigma-Aldrich

SF-1 (EP434) Rabbit Monoclonal Primary Antibody

别名:

Steroidogenic Factor-1

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About This Item

UNSPSC代码:
12352203

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP434, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形式

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (462R-14)
vial of 0.1 mL concentrate Research Use Only (462R-14-RUO)
vial of 0.5 mL concentrate (462R-15)
vial of 1.0 mL concentrate (462R-16)
vial of 1.0 mL concentrate Research Use Only (462R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (462R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (462R-17)
vial of 7.0 mL pre-dilute ready-to-use (462R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (462R-18-RUO)

制造商/商品名称

Cell Marque™

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同位素/亚型

IgG

控制

adrenocortical carcionma, granulosa cell tumor, testis

运输

wet ice

储存温度

2-8°C

可视化

nuclear

基因信息

human ... SF1(7536)

相关类别

一般描述

As both a nuclear receptor and nuclear transcription factor, Steroidogenic factor-1 (SF-1) serves as an important modulator of steroidogenesis. It has been demonstrated that SF-1 serves as a “master regulator” in varying facets of development and function in both reproductive and adrenal tissues. Immunohistochemical detection of SF-1 in testicular tissue may provide value for distinguishing sex-cord stromal tumors, including Leydig cell, Sertoli cell and granulosa cell neoplasms, from other tumors. In addition, SF-1 detection may have utility in distinguishing primary adrenal cortical lesions from their histologic mimics such as renal clear cell carcinoma.

质量


IVD
IVD
IVD
RUO

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Ranna El-Khairi et al.
Seminars in reproductive medicine, 30(5), 374-381 (2012-10-10)
Steroidogenic factor-1 (SF-1) (Ad4BP, NR5A1) is a nuclear receptor that plays a key role in adrenal and reproductive development and function. Deletion of the gene encoding Sf-1 (Nr5a1) in mice results in severe developmental defects of the adrenal gland and
Ankur R Sangoi et al.
The American journal of surgical pathology, 35(5), 678-686 (2011-04-15)
The diagnosis of metastatic clear cell renal cell carcinoma (CC-RCC) can be difficult because of its morphologic heterogeneity and the increasing use of small image-guided biopsies that yield scant diagnostic material. This is further complicated by the degree of morphologic
Chengquan Zhao et al.
The American journal of surgical pathology, 33(3), 354-366 (2008-11-27)
Different immunohistochemical sex cord-stromal markers have been previously studied in various types of ovarian sex cord-stromal tumors; however, the sensitivity for sex cord-stromal lineage may vary between markers, and some markers may not be as sensitive in some types of
Ankur R Sangoi et al.
Applied immunohistochemistry & molecular morphology : AIMM, 21(4), 318-321 (2012-11-21)
Differentiating testicular germ cell tumors from sex-cord stromal tumors can be difficult in certain cases because of overlapping morphologic features and/or an absence of clinically apparent hormonal symptoms. Immunohistochemistry may be needed as an ancillary diagnostic tool in this differential

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