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Merck
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安全信息

451M-1

Sigma-Aldrich

h-Caldesmon (hHCD) Mouse Monoclonal Antibody

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About This Item

UNSPSC代码:
12352203

生物来源

mouse

质量水平

100
500

偶联物

unconjugated

抗体形式

diluted ascites fluid

抗体产品类型

primary antibodies

克隆

hHCD, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形式

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (451M-14)
vial of 0.1 mL concentrate Research Use Only (451M-14-RUO)
vial of 0.5 mL concentrate (451M-15)
vial of 1.0 mL concentrate (451M-16)
vial of 1.0 mL concentrate Research Use Only (451M-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (451M-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (451M-17)
vial of 7.0 mL pre-dilute ready-to-use (451M-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (451M-18-RUO)

制造商/商品名称

Cell Marque™

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 (concentrated)

同位素/亚型

IgG1

控制

bladder, colon, leiomyoma, smooth muscle tumors, stomach

运输

wet ice

储存温度

2-8°C

可视化

cytoplasmic

相关类别

一般描述

Caldesmon is a protein that facilitates the regulation of cellular contraction through complexing with calmodulin, tropomyosin, and actin. Its high molecular weight isoform (h-caldesmon) has been identified to have restricted expression in visceral and vascular smooth muscle cells. In particular, strong expression of h-caldesmon has been observed in non-neoplastic uterine myometrium while being entirely absent in the endometrial layer. In spindle cell tumor pathology, overlapping immunohistochemical staining profiles between smooth muscle cells and myofibroblastic cells has not allowed for reliable identification of true smooth muscle tumors. Immunohistochemical detection of h-caldesmon has been demonstrated to aid in the distinguishing smooth muscle tumors, such as leiomyoma and leiomyosarcoma from myofibroblastic lesions, such as inflammatory myofibroblastic tumors and fibromatoses.

质量


IVD
IVD
IVD
RUO

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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M R Nucci et al.
The American journal of surgical pathology, 25(4), 455-463 (2001-03-21)
Distinction of endometrial stromal neoplasms from cellular smooth muscle tumors of the uterus is sometimes difficult. Immunohistochemistry is often not helpful because muscle actins and desmin are expressed in both neoplasms. This study's goal was to determine whether h-caldesmon, a
K M Ceballos et al.
American journal of clinical pathology, 114(5), 746-753 (2000-11-09)
Misinterpretation of positive staining of antibodies to desmin, smooth muscle actin, and muscle actin as representing smooth muscle differentiation in the context of a spindle cell tumor is not uncommon. Anti-h-caldesmon is a promising novel immunohistochemical reagent for more specific

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