44977
DISBAC2(3), Voltage Sensitive Probe
≥98% (HPLC)
别名:
5-[3-(1,3-Diethylhexahydro-4,6-dioxo-2-thioxo-5-pyrimidinyl)-2-propen-1-ylidene]-1,3-diethyldihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione, Bis(1,3-diethylthiobarbituric acid)trimethine oxonol
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关于此项目
经验公式（希尔记法）:
C19H24N4O4S2
化学文摘社编号:
分子量:
436.55
UNSPSC Code:
12352108
NACRES:
NA.32
PubChem Substance ID:
EC Number:
256-325-5
Beilstein/REAXYS Number:
1232950
MDL number:
InChI key
VJYNRXFXHKIGLT-MDZDMXLPSA-N
InChI
1S/C19H24N4O4S2/c1-5-20-14(24)12(15(25)21(6-2)18(20)28)10-9-11-13-16(26)22(7-3)19(29)23(8-4)17(13)27/h9-12H,5-8H2,1-4H3/b10-9+
SMILES string
CCN1C(=O)C(\C=C\C=C2\C(=O)N(CC)C(=S)N(CC)C2=O)C(=O)N(CC)C1=S
assay
≥98% (HPLC)
fluorescence
λex 535 nm; λem 560 nm in DMSO
suitability
complies for Infrared spectrum
storage temp.
−20°C
Quality Level
Application
DISBAC2(3), Voltage Sensitive Probe is used for single-cell fluorescence imaging of transmembrane conductance and potential change.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
P He et al.
Microvascular research, 50(2), 183-198 (1995-09-01)
The membrane potential is an important modulator of calcium ion flux into endothelial cells of venular microvessels. We developed a method to measure the membrane potential of endothelial cells forming the walls of individually perfused microvessels under the same experimental
M Renier et al.
Human gene therapy, 6(10), 1275-1283 (1995-10-01)
Cystic fibrosis is caused by defects in a chloride-transporting protein termed cystic fibrosis transmembrane conductance regulator (CFTR). This study presents an innovative procedure to evaluate expression of functional CFTR. The technique uses the potential-sensitive probe bis-(1,3-diethylthiobarbituric acid) trimethine oxonol or
A B Al-Mehdi et al.
American journal of respiratory cell and molecular biology, 18(5), 653-661 (1998-06-06)
We hypothesize that lung ischemic injury is related to cessation of flow leading to endothelial cell membrane depolarization and activation of oxidant-generating systems. Cell membrane potential was assessed in isolated, oxygen ventilated, Krebs-Ringer bicarbonate buffer-dextran-perfused rat lungs by lung surface
A G Cabado et al.
Journal of cellular physiology, 158(2), 309-316 (1994-02-01)
We studied, in different ionic conditions, the effect of various agents on the membrane potential of rat peritoneal mast cells using the fluorescent probe bisoxonol. Ouabain and ionophore A23187 lead to a fast depolarization of the plasma membrane of mast
Konstantinos Papadimitriou et al.
International journal of food microbiology, 111(3), 197-205 (2006-08-29)
Flow cytometry in combination with fluorescence probes was applied to rapidly assess the physiological status of Streptococcus macedonicus ACA-DC 198, a newly described member of the lactic acid bacteria group with technologically important features (e.g. lantibiotic production). A sonication procedure
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