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Merck
CN

44714

Sigma-Aldrich

(S)-Mevalonic acid lithium salt

≥96.0% (GC)

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别名:
Lithium (S)-3,5-dihydroxy-3-methyl-pentanoate, Lithium (S)-3,5-dihydroxy-3-methyl-valerate, S-MVA-Li
经验公式(希尔记法):
C6H12O4 · xLi+
CAS号:
分子量:
148.16 (free acid basis)
UNSPSC代码:
12352106
NACRES:
NA.25

质量水平

检测方案

≥96.0% (GC)

旋光性

[α]/D +25.0±3.0°, c = 0.1 in 1 M HCl

储存温度

2-8°C

InChI

1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/t6-/m0/s1

InChI key

KJTLQQUUPVSXIM-LURJTMIESA-N

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生化/生理作用

Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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R R Kopito et al.
Journal of lipid research, 23(4), 577-583 (1982-05-01)
A circadian rhythm in plasma mevalonate was identified in human subjects. This variation, over a 5-fold range, is paralleled by a rhythm in urinary excretion. No such diurnal change in plasma mevalonate was observed in schedule-fed, light-cycled rats, despite the
R A Larson et al.
Blood, 64(1), 257-262 (1984-07-01)
Mevalonic acid can stimulate leukemic cells from some patients with B cell chronic lymphocytic leukemia (CLL) to enter the cell cycle in vitro and to synthesize DNA. Unlike normal human peripheral blood lymphocytes, which require the presence of granulocytes for
Le-Le Hu et al.
PloS one, 6(12), e29491-e29491 (2012-01-06)
Given a compound, how can we effectively predict its biological function? It is a fundamentally important problem because the information thus obtained may benefit the understanding of many basic biological processes and provide useful clues for drug design. In this
Priti Agarwal et al.
The Journal of investigative dermatology, 135(4), 1080-1088 (2014-12-19)
Vitiligo is a common autoimmune disease of the skin that results in disfiguring white spots. There are no Food and Drug Administration (FDA)-approved treatments, and current treatments are time-consuming, expensive, and of low efficacy. We sought to identify new treatments

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