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Merck
CN

446R-1

Steroidogenic Acute Regulatory Protein (STAR) (EP226) Rabbit Monoclonal Primary Antibody

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关于此项目

UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
EP226, monoclonal
Application:
IHC (p)
Citations:
3

主要文件

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biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP226, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (446R-14), vial of 0.1 mL concentrate Research Use Only (446R-14-RUO), vial of 0.5 mL concentrate (446R-15), vial of 1.0 mL concentrate (446R-16), vial of 1.0 mL concentrate Research Use Only (446R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (446R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (446R-17), vial of 7.0 mL pre-dilute ready-to-use (446R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (446R-18-RUO)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

isotype

IgG

control

adrenal cortex

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... STAR(6770)

General description

Steroidogenic Acute Regulatory Protein (STAR) is a sterol transfer protein that is critical for steroidegenesis. Steroidegenesis is the process where steroid hormones are made within specialized cells. STAR controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone. Immunohistochemically, STAR is a cytoplasmic marker that is generally localized in the normal and neoplastic cells of steroid hormone producing tissues such as testis and adrenal gland. Due to their low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, this antibody may assist in differentiating sex cord stromal tumors, seminomas and embryonal carcinomas.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note


IVD
IVD
IVD
RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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S E Pollack et al.
The Journal of clinical endocrinology and metabolism, 82(12), 4243-4251 (1997-12-17)
The rate-limiting step in steroid hormone production in the adrenal cortex and gonads, the translocation of cholesterol from the outer to the inner mitochondrial membranes, is mediated by the steroidogenic acute regulatory protein (StAR). Heretofore, the localization of StAR in
C B Kallen et al.
The Journal of biological chemistry, 273(41), 26285-26288 (1998-10-03)
Steroidogenic acute regulatory protein (StAR) plays a critical role in steroidogenesis by enhancing the delivery of substrate cholesterol from the outer mitochondrial membrane to the cholesterol side chain cleavage enzyme system on the inner membrane. A recombinant StAR protein lacking
Chih-Hsien Chin et al.
The Chinese journal of physiology, 51(1), 54-61 (2008-06-17)
We report production of a polyclonal antibody against the StAR (steroidogenic acute regulatory) protein of steroidogenic cells and immunohistochemistry (IHC) staining of bovine adrenal gland tissue available in paraffin block. The epitope-specific polyclonal antibody was produced in a rabbit immunized

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