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安全信息

443R-1

Sigma-Aldrich

Nanog (EP225) Rabbit Monoclonal Primary Antibody

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UNSPSC代码:
12352203

生物来源

rabbit

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP225, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形式

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (443R-14)
vial of 0.1 mL concentrate Research Use Only (443R-14-RUO)
vial of 0.5 mL concentrate (443R-15)
vial of 1.0 mL concentrate (443R-16)
vial of 1.0 mL concentrate Research Use Only (443R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (443R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (443R-17)
vial of 7.0 mL pre-dilute ready-to-use (443R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (443R-18-RUO)

制造商/商品名称

Cell Marque™

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 (concentrated)

同位素/亚型

IgG

控制

seminoma

运输

wet ice

储存温度

2-8°C

可视化

nuclear

基因信息

human ... NANOG(79923)

相关类别

一般描述

Nanog is a transcription factor homeoprotein that is involved in maintaining embryonic stem cell pluripotency and self-renewal. Embryonic stem cells with a deleted Nanog gene lose pluripotency. Conversely, embryonic stem cells that are forced to differentiate will downregulate Nanog expression. Nanog expression has been shown to be absent in normal adult organ tissues, but positive expression in undifferentiated germ cell tumors such as seminoma, dysgerminoma and embryonal carcinoma has been noted. Therefore, Nanog may be used as an aid in the determination of undifferentiated tumors of germ cell origin from non-germ cell tumors.

质量


IVD
IVD
IVD
RUO

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

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Martin C Chang et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 28(4), 347-355 (2009-06-02)
The embryonic stem cell transcription factors SOX2, NANOG, and OCT3/4 are involved in the regulation of germ cell tumor growth and differentiation. They, and D2-40 (podoplanin), an antigen expressed in seminomas, are emerging as useful diagnostic markers in testicular germ
Adam H Hart et al.
Cancer, 104(10), 2092-2098 (2005-10-06)
The NANOG gene, a member of the homeobox family of DNA binding transcription factors, was recently identified in a screen for pluripotency-promoting genes. NANOG overexpression in murine embryonic stem cells is sufficient to maintain self-renewal and to block differentiation. The
Ian Chambers et al.
Cell, 113(5), 643-655 (2003-06-06)
Embryonic stem (ES) cells undergo extended proliferation while remaining poised for multilineage differentiation. A unique network of transcription factors may characterize self-renewal and simultaneously suppress differentiation. We applied expression cloning in mouse ES cells to isolate a self-renewal determinant. Nanog
Guangjin Pan et al.
Cell research, 17(1), 42-49 (2007-01-11)
Several extrinsic signals such as LIF, BMP and Wnt can support the self-renewal and pluripotency of embryonic stem (ES) cells through regulating the "pluripotent genes." A unique homeobox transcription factor, Nanog, is one of the key downstream effectors of these
Kaoru Mitsui et al.
Cell, 113(5), 631-642 (2003-06-06)
Embryonic stem (ES) cells derived from the inner cell mass (ICM) of blastocysts grow infinitely while maintaining pluripotency. Leukemia inhibitory factor (LIF) can maintain self-renewal of mouse ES cells through activation of Stat3. However, LIF/Stat3 is dispensable for maintenance of

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