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应用
来自兔的促凝血酶原激酶已用于:
- 作为组织因子促凝活性测定（TF-PCA）的标准品
- 肺栓塞试验
- 作为人血浆凝血试验中的阳性对照
生化/生理作用
凝血活酶（组织因子）是一种跨膜蛋白，是血液凝固的主要体内激活剂，可导致凝血酶的生成和纤维蛋白的沉积。它在凝血蛋白酶级联的激活中也很重要，并参与了脓毒症的致死性。
来自兔的促凝血酶原激酶可用于在动物模型中产生弥散性血管内凝血（DIC）。
包装
一个含3-4 mg凝血活酶的小瓶。
重悬
将小瓶中的内容物重溶于4 ml 10 mm CaCl2中
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 1
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
J Erlich et al.
Infection and immunity, 67(5), 2540-2546 (1999-05-04)
Tissue factor (TF) is the major activator of the coagulation protease cascade and contributes to lethality in sepsis. Despite several studies analyzing TF expression in animal models of endotoxemia, there remains debate about the cell types that are induced to
Line Olrik Berthelsen et al.
Thrombosis research, 126(4), 337-344 (2010-07-20)
Validation of animal models of disseminated intravascular coagulation (DIC) to human DIC is crucial in order to translate findings in research models to treatment modalities for DIC in humans. ISTH classifications of overt and non-overt human DIC have proven to
M E Bromberg et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(18), 8205-8209 (1995-08-29)
Several studies have established a link between blood coagulation and cancer, and more specifically between tissue factor (TF), a transmembrane protein involved in initiating blood coagulation, and tumor metastasis. In the study reported here, a murine model of human melanoma
Esterina D'Asti et al.
Methods in molecular biology (Clifton, N.J.), 1458, 39-58 (2016-09-02)
Angiogenesis represents one aspect in the complex process that leads to the generation of the vascular tumor stroma. The related functional constituents include responses of endothelial, mural, bone marrow-derived, and resident inflammatory cells as well as activation of coagulation and
Nan Zhang et al.
The Journal of experimental medicine, 216(6), 1291-1300 (2019-05-03)
Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages in mice promotes bacterial clearance in
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