生物来源
rabbit
质量水平
100
500
偶联物
unconjugated
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
EP140, monoclonal
描述
(For In Vitro Diagnostic Use in Select Regions (See Chart))
形式
buffered aqueous solution
种属反应性
human
包装
bottle of 1.0 mL predilute (439R-17)
bottle of 7.0 mL predilute (439R-18)
vial of 0.1 mL concentrate (439R-14)
vial of 0.5 mL concentrate (439R-15)
vial of 1.0 mL concentrate (439R-16)
制造商/商品名称
Cell Marque™
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
同位素/亚型
IgG
运输
wet ice
储存温度
2-8°C
基因信息
human ... MSLN(10232)
一般描述
Mesothelin is a 40 kDa glycosyl-phosphatudylinositol-anchored glycoprotein cleaved from a 71kDa precursor protein encoded by the human mesothelin gene. Mesothelin is present on the surface of normal mesothelial cells.1 Although the function of mesothelin is unknown, it is overexpressed in a wide variety of cancers including mesothelioma, pancreatic ductal adenocarcinoma, and ovarian carcinoma.1-6 Mesothelin has proven to be a valuable marker for pancreatic ductal adenocarcinoma due to its strong reactivity in tumor tissue and absence in normal pancreas.1, 3-4 Metastatic renal cell carcinoma can present clinical patterns that mimic primary mesothelioma, pancreatic ductal adenocarcinoma, and ovarian carcinoma.2, 4-6 Mesothelin has demonstrated utility in the differential diagnosis between these primary tumors and corresponding metastatic renal cell carcinoma within the context of an antibody panel.4-6
质量
 IVD |  IVD |  IVD |  RUO |
联系
Mesothelin Positive Control Slides, Product No. 439S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
制备说明
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Viviane Gnemmi et al.
Analytical and quantitative cytopathology and histopathology, 35(3), 157-162 (2013-12-19)
To determine whether PAX2 and mesothelin immunohistochemistry add additional diagnostic value in discriminating between pancreatic metastasis of renal clear cell carcinoma (PMRCC) and primary ductal adenocarcinoma of the pancreas (PDAC). We retrospectively collected tissue from PMRCC and PDAC. Eleven cases
Nelson G Ordóñez
Human pathology, 35(6), 697-710 (2004-06-10)
Both mesotheliomas and renal cell carcinomas can present a wide variety of morphological patterns. Because of this, renal cell carcinomas that metastasize to the pleura and lung may be confused with mesotheliomas. The aim of the present study was to
Nelson G Ordóñez
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 16(3), 192-197 (2003-03-18)
Mesothelin is a cell surface antigen of unknown function that is strongly expressed in mesothelial cells. Although it was reported in 1992 that immunostaining with the K1 anti-mesothelin antibody could be very useful in distinguishing between epithelioid mesotheliomas and pulmonary
Erolcan Sayar et al.
JCI insight, 8(7) (2023-02-24)
Prostate-specific membrane antigen (PSMA) is an important cell surface target in prostate cancer. There are limited data on the heterogeneity of PSMA tissue expression in metastatic castration-resistant prostate cancer (mCRPC). Furthermore, the mechanisms regulating PSMA expression (encoded by the FOLH1
Diagnostic value of cytokeratin 7, CD10 and mesothelin in distinguishing ovarian clear cell carcinoma from metastasis of renal clear cell carcinoma.
X Leroy et al.
Histopathology, 51(6), 874-876 (2007-11-29)
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