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生物来源
mouse
偶联物
unconjugated
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
2297, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
表单
buffered aqueous solution
种属反应性
human
包装
vial of 0.1 mL concentrate (412M-14)
vial of 0.5 mL concentrate (412M-15)
bottle of 1.0 mL predilute (412M-17)
vial of 1.0 mL concentrate (412M-16)
bottle of 7.0 mL predilute (412M-18)
制造商/商品名称
Cell Marque®
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
同位素/亚型
IgG1
控制
Ewing’s sarcoma, mesothelioma
运输
wet ice
储存温度
2-8°C
可视化
membranous
基因信息
human ... CAV1(857)
一般描述
Caveolin-1 (CAV-1) is a cell membrane-associated structural component of flask-shaped plasma membrane invaginations termed caveolae. CAV-1 is expressed at different levels in different tissues, with the highest in adipocytes, endothelial cells, fibroblasts, and mesothelial cells. Anti-CAV-1 is useful in assisting in the identification of epithelioid mesothelioma. A study by Amatya et al. indicates CAV-1 expression in all 80 (100%) epithelioid mesotheliomas, whereas only 6/80 (7.5%) of the lung adenocarcinomas were positive for CAV-1. Staining in most mesotheliomas was strong and diffuse when compared with the weak, focal staining (no more than 1% of the tumor cells) seen in the lung adenocarcinomas, anti-CAV-1 is considered a very useful marker for assisting in discriminating between these two malignancies. They also indicated that anti-CAV-1 is comparable to other mesothelioma markers such as anti-calretinin and anti-D2-40 (podoplanin) that are commonly used to assist in the differentiation between epithelioid mesotheliomas and lung adenocarcinomas. Anti-CAV-1 is also useful in identification of Ewing sarcoma/PNET. Literature indicates CAV-1 expression in 368 (96%) of 383 cases of Ewing sarcoma/PNET. In summary, anti-CAV-1 is very useful in the differentiation of epithelioid mesothelioma from lung adenocarcinoma and identification of Ewing sarcoma/PNET.
质量
 IVD |  IVD |  IVD |  RUO |
联系
Caveolin-1 Positive Control Slides, Product No. 412S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
制备说明
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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法规信息
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历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Alex W Cohen et al.
Physiological reviews, 84(4), 1341-1379 (2004-09-24)
Although they were discovered more than 50 years ago, caveolae have remained enigmatic plasmalemmal organelles. With their characteristic "flasklike" shape and virtually ubiquitous tissue distribution, these interesting structures have been implicated in a wide range of cellular functions. Similar to
Antonio Llombart-Bosch et al.
Virchows Archiv : an international journal of pathology, 455(5), 397-411 (2009-10-21)
Ewing's sarcoma (ES)/peripheral neuroectodermal tumor (PNET) are malignant neoplasms affecting children and young adults. We performed a study to typify the histological diversity and evaluate antibodies that may offer diagnostic/prognostic support. In total, 415 cases of genetically confirmed paraffin-embedded ES/PNET
Vishwa Jeet Amatya et al.
Histopathology, 55(1), 10-19 (2009-07-21)
The incidence of mesothelioma is increasing in Europe, Japan and other developing countries. There is difficulty in the accurate diagnosis of mesothelioma and its differentiation from lung adenocarcinoma. Mesothelioma shows a complex immunohistochemical profile. Therefore, the use of a immunohistochemical
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