biological source
mouse
conjugate
unconjugated
antibody form
diluted ascites fluid
antibody product type
primary antibodies
clone
1F5, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (401M-14)
vial of 0.5 mL concentrate (401M-15)
bottle of 1.0 mL predilute (401M-17)
vial of 1.0 mL concentrate (401M-16)
bottle of 7.0 mL predilute (401M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
isotype
IgG2a
control
synovial sarcoma
shipped in
wet ice
storage temp.
2-8°C
visualization
nuclear
Gene Information
human ... TLE1(7088)
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
Transducin-like enhancer protein 1 (TLE1) is a protein encoded by the gene TLE1 and is involved in the control of hematopoiesis, neuronal, and terminal epithelial differentiation. Positive immunohistochemical nuclear staining with anti-TLE1 has been shown to be useful for identifying synovial sarcoma. TLE1 expression may also be observed in other soft tissue neoplasms, usually at low levels.
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
TLE1 Positive Control Slides, Product No. 401S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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此项目有
Marc El Beaino et al.
Sarcoma, 2020, 7192347-7192347 (2020-04-24)
Synovial sarcoma can present morphologically in multiple forms, including biphasic and monophasic subtypes. As a result, the histological diagnosis can sometimes be challenging. Transducin-Like Enhancer 1 (TLE1) is a transcriptional corepressor that normally is involved in embryogenesis and hematopoiesis but
Kemal Kosemehmetoglu et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(7), 872-878 (2009-04-14)
TLE1, a transcriptional repressor essential in hematopoiesis, neuronal differentiation and terminal epithelial differentiation, has recently been shown in a single tissue microarray study to be a highly sensitive and relatively specific marker of synovial sarcomas. Expression of TLE1 has not
Amanda Jagdis et al.
The American journal of surgical pathology, 33(12), 1743-1751 (2009-10-08)
Synovial sarcoma is a high-grade soft tissue sarcoma that can be challenging to diagnose on the basis of histology alone. It is defined by a characteristic translocation t(X;18) that produces the fusion oncogene SYT-SSX. The current diagnostic gold standard for
Jefferson Terry et al.
The American journal of surgical pathology, 31(2), 240-246 (2007-01-27)
Synovial sarcoma is a soft tissue malignancy defined by the SYT-SSX fusion oncogene. Demonstration of the t(X;18) by cytogenetics, fluorescence in situ hybridization or reverse-transcriptase polymerase chain reaction has become the gold standard for diagnosis, but practical considerations limit the
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