39235
11-[5-(Dimethylamino)-1-naphthalenesulfonylamino]undecanoic acid
BioReagent, suitable for fluorescence, ≥98.0% (TLC)
别名:
11-(Dansylamino)undecanoic acid, DAUDA
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关于此项目
经验公式（希尔记法）:
C23H34N2O4S
化学文摘社编号:
分子量:
434.59
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
8946533
MDL number:
SMILES string
CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCCCCCCC(O)=O
InChI
1S/C23H34N2O4S/c1-25(2)21-15-11-14-20-19(21)13-12-16-22(20)30(28,29)24-18-10-8-6-4-3-5-7-9-17-23(26)27/h11-16,24H,3-10,17-18H2,1-2H3,(H,26,27)
InChI key
CEPGVMDMVJGHFQ-UHFFFAOYSA-N
product line
BioReagent
assay
≥98.0% (TLC)
solubility
DMSO: soluble, methanol: soluble
fluorescence
λex 335 nm; λem 516 nm in methanol
suitability
suitable for fluorescence
storage temp.
2-8°C
Application
11-[5-(Dimethylamino)-1-naphthalenesulfonylamino]undecanoic acid (DAUDA), a dansyl-type fluorophore, is widely used as a hydrophobic binding site probe to identify and characterize the binding sites of medium chain fatty acids, their derivatives and other hydrophobic compounds on molecules such as proteins.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
HPLC determination of fatty acid binding proteins in rat liver with fluorescence detection
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
A E Thumser et al.
The Biochemical journal, 314 ( Pt 3), 943-949 (1996-03-15)
Rat liver fatty acid-binding protein (FABP) is able to accommodate a wide range of non-polar anions in addition to long-chain fatty acids. This property means that the liver protein is functionally different from other FABPs from intestine, muscle and adipose
O K Gasymov et al.
Biochimica et biophysica acta, 1433(1-2), 307-320 (1999-10-09)
The principal lipid binding protein in tears, tear lipocalin (TL), binds acid and the fluorescent fatty acid analogs, DAUDA and 16-AP at one site TL compete for this binding site. A fluorescent competitive binding assay revealed that apo-TL has a
A E Thumser et al.
The Biochemical journal, 320 ( Pt 3), 729-733 (1996-12-15)
The physiological role of liver fatty acid-binding protein (L-FABP) has yet to be clarified. An important feature of this member of the family of intracellular lipid-binding proteins is the wide range of compounds that have been identified as potential physiological
Matthew W Elmes et al.
Scientific reports, 9(1), 7588-7588 (2019-05-22)
The increasing use of medical marijuana highlights the importance of developing a better understanding of cannabinoid metabolism. Phytocannabinoids, including ∆9-tetrahydrocannabinol (THC), are metabolized and inactivated by cytochrome P450 enzymes primarily within the liver. The lipophilic nature of cannabinoids necessitates mechanism(s)
Fen Qiao et al.
PloS one, 11(8), e0160003-e0160003 (2016-08-02)
Heterodera avenae and H. filipjevi are major parasites of wheat, reducing production worldwide. Both are sedentary endoparasitic nematodes, and their development and parasitism depend strongly on nutrients obtained from hosts. Secreted fatty acid- and retinol-binding (FAR) proteins are nematode-specific lipid
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