biological source
rabbit
conjugate
unconjugated
antibody form
Ig fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (383A-74)
vial of 0.5 mL concentrate (383A-75)
bottle of 1.0 mL predilute (383A-77)
vial of 1.0 mL concentrate (383A-76)
bottle of 7.0 mL predilute (383A-78)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
control
melanoma, schwannoma, skin melanocytes
shipped in
wet ice
storage temp.
2-8°C
visualization
nuclear
Gene Information
human ... SOX10(6663)
mouse ... Sox10(20665)
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
Sry-related HMG-BOX gene 10, (SOX-10), a nuclear transcription factor that participates in neural crest development and in the specification and differentiation of cells of melanocytic lineage, has been recently shown to be a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. SOX-10 nuclear expression was found in 76 of 78 melanomas (97%) and 38 of 77 malignant peripheral nerve sheath tumors (49%), whereas S100 protein was expressed in 71 melanomas (91%) and 23 malignant peripheral nerve sheath tumors (30%). SOX-10 was expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells which usually express S100 protein. It is known that the commonly used melanoma markers, anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while it has been reported that anti-SOX-10 was moderately to strongly expressed in all of the 28 desmoplastic melanomas tested. SOX-10 is less likely expressed by background fibrocytes and histiocytes in exicion scar than S100 and MiTF. Therefore, anti-SOX-10 is considered a very reliable marker for recognizing residual demoplastic melanoma.
SOX-10 is diffusely expressed in schwannomas and neurofibromas. SOX-10 reaction is not identified in any other mesenchymal and epithelial tumors except for myoepitheliomas and diffuse astrocytomas. SOX-10 expression is seen in sustentacular cells of pheochromocytomas and paragangliomas, and occasionally carcinoid tumors from various organs, but not in the tumor cells.
In normal tissues, SOX-10 is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial, eccrine, and mammary glands. SOX-10 expression is also observed in mast cells in a variety of tissues and organs in both nuclear and cytoplasmic reaction.
SOX-10 is diffusely expressed in schwannomas and neurofibromas. SOX-10 reaction is not identified in any other mesenchymal and epithelial tumors except for myoepitheliomas and diffuse astrocytomas. SOX-10 expression is seen in sustentacular cells of pheochromocytomas and paragangliomas, and occasionally carcinoid tumors from various organs, but not in the tumor cells.
In normal tissues, SOX-10 is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial, eccrine, and mammary glands. SOX-10 expression is also observed in mast cells in a variety of tissues and organs in both nuclear and cytoplasmic reaction.
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
SOX-10 Positive Control Slides, Product No. 383S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
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For both vertebrate developmental and evolutionary biologists, and also for clinicians, the neural crest (NC) is a fundamental cell population. An understanding of Sox10 function in NC development is of particular significance since Sox10 mutations underlie several neurocristopathies. Surprisingly, experiments
T A Longacre et al.
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The clinical, histologic, and immunohistologic features of 22 desmoplastic melanomas (DMM), 10 mixed desmoplastic and spindle-cell melanomas (DMM/SMM), and two cellular spindle-cell melanomas (SMM) were studied. Patients ranged in age from 35 to 91 years (mean, 67) and included 23
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IHC antibodies enhance dermatopathology beyond H&E stained slides, improving techniques and applications for dermatological research.
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