biological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
MRQ-58, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (382M-14)
vial of 0.5 mL concentrate (382M-15)
bottle of 1.0 mL predilute (382M-17)
vial of 1.0 mL concentrate (382M-16)
bottle of 7.0 mL predilute (382M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
isotype
IgG1
control
mantle cell lymphoma
shipped in
wet ice
storage temp.
2-8°C
visualization
nuclear
Gene Information
human ... SOX11(6664)
Other Notes
SOX-11 Positive Control Slides, Product No. 382S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
SOX-11 which is a member of the SOX (SRY-related HMG-box) family is a transcription factor normally expressed in the developing human central nervous system and plays a role in embryonic cell determination. citation Studies show that SOX-11 can be used as a marker for mantle cell lymphoma (MCL).
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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此项目有
Mantle cell lymphoma: from pathology and molecular pathogenesis to new therapeutic perspectives.
Itziar Salaverria et al.
Haematologica, 91(1), 11-16 (2006-01-26)
Tiemo Katzenberger et al.
British journal of haematology, 142(4), 538-550 (2008-06-20)
Mantle cell lymphoma (MCL) is an aggressive lymphoid tumour characterized by the translocation t(11;14)(q13;q32) and a poor clinical outcome (median survival: 3-4 years). Recent studies revealed that increased proliferation of the tumour cells and certain chromosomal aberrations, such as deletions
Bernd Weigle et al.
Oncology reports, 13(1), 139-144 (2004-12-08)
Malignant glioma comprises the majority of primary human brain tumors with 16,800 new cases reported each year in the USA. Its prognosis remains dismal despite numerous attempts to improve conventional therapeutic modalities. Therefore, much effort is devoted to the exploration
Roshni Narurkar et al.
Biomarker research, 4, 6-6 (2016-03-08)
Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathognomonic hallmarks of mantle cell lymphoma (MCL). However, there have been cases that lacked both t(11;14) and cyclin D1 protein but still had a gene expression profile suggesting a
Weifen Zeng et al.
The American journal of surgical pathology, 36(2), 214-219 (2012-01-19)
SOX11 expression has been recently shown to be useful in the diagnosis of mantle cell lymphoma (MCL), including cyclin D1-negative MCL with typical morphology. We evaluated SOX11 expression pattern in B-cell non-Hodgkin lymphoma (B-NHL) subtypes to confirm specificity and used
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