跳转至内容
Merck
CN
所有图片(1)

文件

安全信息

380R-2

Sigma-Aldrich

Arginase-1 (EP261) Rabbit Monoclonal Primary Antibody

登录查看公司和协议定价
所有图片(1)
UNSPSC代码:
12352203

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP261, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形式

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (380R-24)
vial of 0.1 mL concentrate Research Use Only (380R-24-RUO)
vial of 0.5 mL concentrate (380R-25)
vial of 1.0 mL concentrate (380R-26)
vial of 1.0 mL concentrate Research Use Only (380R-26-RUO)
vial of 1.0 mL pre-dilute Research Use Only (380R-27-RUO)
vial of 1.0 mL pre-dilute ready-to-use (380R-27)
vial of 7.0 mL pre-dilute ready-to-use (380R-28)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (380R-28-RUO)

制造商/商品名称

Cell Marque™

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 (concentrated)

同位素/亚型

IgG

控制

hepatocellular carcinoma, normal liver

运输

wet ice

储存温度

2-8°C

可视化

cytoplasmic, nuclear

基因信息

human ... ARG1(383)

一般描述

Arginase-1 is a key urea cycle metalloenzyme that has demonstrated expression in normal human liver with a high degree of specificity. Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver accounting for an estimated 70%-85% of total liver cancers worldwide. Diagnostic pitfalls exist in the morphologic distinction of HCC from other hepatocellular and non-hepatocellular lesions. In difficult or equivocal cases, the application of immunohistochemical (IHC) panels has been shown to aid in the distinction of benign and malignant liver lesions. In sections of normal liver, anti-arginase-1 produced strong, diffuse cytoplasmic reactivity in all hepatocytes throughout the lobule. In some cases, patchy nuclear reactivity is also evident in hepatocytes along with the cytoplasmic reactivity. Reactivity is not observed in bile duct epithelial cells, sinusoidal endothelial cells, Kupffer cells, or vascular endothelial cells. In sections of HCC, anti-arginase-1 produces cytoplasmic or cytoplasmic plus nuclear reactivity.

质量


IVD
IVD
IVD
RUO

联系

Arginase-1 Positive Control Slides, Product No. 380S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 2

法规信息

监管及禁止进口产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Nehal A Radwan et al.
Diagnostic pathology, 7, 149-149 (2012-11-01)
The ability to distinguish hepatocellular carcinoma (HCC) from metastatic carcinoma (MC) involving the liver and cholangiocarcinoma (CC) by immunohistochemistry has been limited by the lack of a reliable positive marker for hepatocellular differentiation. Arginase-1 is a marker for HCC recently
Benign and malignant tumors of the liver.
LINDA D. FERRELL
Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas, 2nd ed., Pages 1291-Pages 1325 (2009)
Thuy Nguyen et al.
Archives of pathology & laboratory medicine, 139(8), 1028-1034 (2015-08-01)
Several immunohistochemical markers are available to establish the diagnosis of hepatocellular carcinoma. Judicious selection is essential to achieve a reliable diagnosis in limited tissue provided by liver biopsy. To compare the efficacy of 5 hepatocellular markers for the diagnosis of
Ahmedin Jemal et al.
CA: a cancer journal for clinicians, 61(2), 69-90 (2011-02-08)
The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors, particularly smoking, in economically developing countries. Based on the GLOBOCAN 2008 estimates, about 12.7
T H Niemann et al.
Cancer, 87(5), 295-298 (1999-10-28)
Fine-needle aspiration biopsy (FNAB) is frequently used to diagnose mass lesions in the liver. Differentiating metastatic adenocarcinoma from primary hepatocellular carcinoma can be difficult. Despite a number of morphologic criteria, there remain occasional cases in which the cytologic features fail
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门