生物来源
rabbit
质量水平
100
500
偶联物
unconjugated
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
EP103, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions
形式
buffered aqueous solution
种属反应性
human
包装
vial of 0.1 mL concentrate (371R-24)
vial of 0.1 mL concentrate Research Use Only (371R-24-RUO)
vial of 0.5 mL concentrate (371R-25)
vial of 1.0 mL concentrate (371R-26)
vial of 1.0 mL concentrate Research Use Only (371R-26-RUO)
vial of 1.0 mL pre-dilute Research Use Only (371R-27-RUO)
vial of 1.0 mL pre-dilute ready-to-use (371R-27)
vial of 7.0 mL pre-dilute ready-to-use (371R-28)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (371R-28-RUO)
制造商/商品名称
Cell Marque™
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 (concentrated)
同位素/亚型
IgG
控制
squamous carcinoma (lung)
运输
wet ice
储存温度
2-8°C
可视化
nuclear
基因信息
human ... SOX2(6657)
一般描述
The differentiation of seminomas from non-seminomatous germ cell tumors can be challenging, especially, if small biopsy specimens, necrotic tumors and metastatic tumors with artifacts are encountered. A subset of germ cell tumors may require immunohistochemistry (IHC) for classification owing to unusual morphologic features, such as diffuse growth of clear cells, and tumors with glandular and/or microcytic patterns. In the mixed germ cell tumor, one component is often intermingled intimately with others such as embryonal carcinoma versus yolk sac tumor, can be overlooked. IHC will identify such an area and allow for the identification of each component of the mixed tumor more accurately and documenting them in the pathology report is recommended by WHO. Current IHC studies have shown the combination of CD30/CD117 staining plays a good role in distinguishing between embryonal carcinoma and yolk sac tumor. However, a subset of tumors may not be distinguished by this combination. Also, the characteristic membranous pattern by antibodies to CD30 and CD117 for the interpretation of the diagnosis may not be evident in limited biopsy specimens. In this respect, transcription factors, such as SOX-2, are easier to interpret due to their distinct nuclear reaction. SOX-2 has been reported as a diagnostic marker for embryonal carcinoma. SOX-2 was expressed in intratubular embryonal carcinoma, pure embryonal carcinoma and in the embryonal carcinoma component of mixed germ cell tumor in all cases. But, SOX-2 expression has not been found in seminoma, yolk sac tumor, and choriocarcinoma in almost all cases. An inclusion of transcription factors, like SOX-2 and SOX-17, in a panel of IHC is useful for the classification of germ cell tumors: that is, SOX-2+/OCT3/4+/CD30+/CD117-/SOX17- for embryonal carcinoma; SOX-2-/OCT3/4+/CD30-/CD117+/SOX17+ for seminoma; SOX-2-/OCT3/4-/CD30-/CD117-/SOX17- for yolk sac tumor.
质量
 IVD |  IVD |  IVD |  RUO |
联系
SOX-2 Positive Control Slides, Product No. 371S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
制备说明
Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.
Download the latest released IFU
Note: This IFU may not apply to your specific product lot.
Note: This requires a keycode which can be found on your packaging or product label.
Download the latest released IFU
Note: This IFU may not apply to your specific product lot.
其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Daisuke Nonaka
American journal of clinical pathology, 131(5), 731-736 (2009-04-17)
Testicular germ cell tumors (GCTs) are subclassified to seminoma and nonseminomatous GCT for the purpose of treatment and prognostication. This study examined SOX2 and SOX17 expression patterns in a total of 67 cases, including 41 pure GCTs (32 seminomas and
Tumors of the testis and paratesticular tissue
Woodward PJ et al.
Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs, Pages 217-Pages 278 (2004)
I A Sesterhenn et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 10(1), 69-78 (1992-01-01)
The Testicular Cancer Intergroup Study (TCIS) was undertaken to evaluate the pathologic findings in early-stage testicular cancer as determined by central pathology review, to compare these findings with the interpretation by the contributing pathologists, and to make correlations with various
Sandro Santagata et al.
The American journal of surgical pathology, 31(6), 836-845 (2007-05-29)
The core embryonic stem cell transcription factors (TFs) OCT3/4 (OCT4), NANOG, and SOX2 have shared as well as nonoverlapping roles in stem cell growth and differentiation. These same TFs are also expressed in various types of human germ cell tumors
Robert E Emerson et al.
Seminars in diagnostic pathology, 22(1), 33-50 (2006-03-04)
Although most testicular and paratesticular tumors can be recognized by their light microscopic features, some raise significant differential diagnostic questions. Immunohistochemical staining has proved of significant value in this situation. There is still a role for the traditional markers, including
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