biological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
MRQ-50, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (363M-14)
vial of 0.5 mL concentrate (363M-15)
bottle of 1.0 mL predilute (363M-17)
vial of 1.0 mL concentrate (363M-16)
bottle of 7.0 mL predilute (363M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry: 1:50-1:200
isotype
IgG
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... PAX8(7849)
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
PAX-8 is a transcription factor expressed during embryonic development of Müllerian organs, kidneys, and thyroid, with continued expression in some epithelial cell types of these mature tissues.PAX-8 is a useful marker for neoplasms of gynecologic renal and thyroidorigin.PAX-8 (MRQ-50) antibody targets the N-terminus of the PAX-8 molecule. This section of the protein is shared with other PAX proteins such as PAX-5 and PAX-6; thus, some cross-reactivity with these proteins may be observed as evidenced by the labeling of selected lymphocytes, and neuroendocrine cells.
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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此项目有
Nelson G Ordóñez
Advances in anatomic pathology, 19(3), 140-151 (2012-04-14)
PAX 8 is a transcription factor involved in the regulation of organogenesis of the thyroid gland, kidney, and Müllerian system. Recent studies have shown that, among tumors, PAX 8 is commonly expressed in epithelial tumors of the thyroid and parathyroid
Mark J Mentrikoski et al.
Applied immunohistochemistry & molecular morphology : AIMM, 22(9), 635-641 (2014-10-04)
Clear-cell renal cell carcinoma (CC-RCC) is the most common primary kidney malignancy, yet this morphology is not unique to renal primary tumors, as clear-cell variants of numerous nonrenal carcinomas of varying lineages exist. Therefore, because of CC-RCC's ability to metastasize
Meaghan L Barr et al.
Journal of clinical pathology, 68(1), 12-17 (2014-10-16)
Immunohistochemical stains have greatly improved the diagnostic accuracy of renal cell carcinoma (RCC) for primary and distant tumours. We evaluate a marker that has recently been incorporated in clinical practice, PAX-8, in primary and metastatic RCCs. Two distinct tissue microarrays
Inigo Espinosa et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 34(3), 257-265 (2015-04-07)
Breast carcinomas rarely metastasize to the ovary and are even more rarely present clinically as primary ovarian tumors. However, patients with breast cancer not infrequently develop independent primary ovarian carcinomas. In these cases, distinction between independent primaries and metastatic tumors
Control of sheath back bleeding: a simplified approach.
G I Gabliani et al.
Catheterization and cardiovascular diagnosis, 13(6), 427-427 (1987-11-01)
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