biological source
rabbit
conjugate
unconjugated
antibody form
Ig fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (363A-14)
vial of 0.5 mL concentrate (363A-15)
bottle of 1.0 mL predilute (363A-17)
bottle of 7.0 mL predilute (363A-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry: 1:25-1:100
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... PAX8(7849)
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
PAX-8 is a transcription factor expressed during the embryonic development of Müllerian organs,kidneys, and thyroid, with continued expression in some epithelial cell types of these maturetissues. PAX-8 is a useful marker for neoplasms of gynecologic, renal, and thyroidorigin. This antibody targets the N-terminus of the PAX-8 molecule. This section of the protein isshared with other PAX proteins such as PAX-5 and PAX-6; thus, some cross-reactivitywith these proteins may be observed as evidenced by the labeling of selected lymphocytes, andneuroendocrine cells.
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Ping Zhang et al.
Pathology international, 56(5), 240-245 (2006-05-04)
Thyroid transcription factor 1 (TTF1), thyroid transcription factor 2 (TTF2) and paired box gene 8 (Pax8) are demonstrated to play a crucial role for the differentiation and organogenesis of thyroid follicular cells. Their roles in thyroid carcinogenesis are not very
Biljana Pauzar et al.
Collegium antropologicum, 36 Suppl 2, 79-82 (2013-02-13)
US-guided fine needle aspiration cytology is currently the best diagnostic tool for thyroid nodules. However, it is not sensitive and specific enough for differentiating between benign and malignant follicular tumors. A potentially useful marker for this differentiation is the PAX8-PPARgamma
Control of sheath back bleeding: a simplified approach.
G I Gabliani et al.
Catheterization and cardiovascular diagnosis, 13(6), 427-427 (1987-11-01)
Tina Di Palma et al.
The Journal of biological chemistry, 278(5), 3395-3402 (2002-11-21)
Pax genes encode for transcription factors essential for tissue development in many species. Pax8, the only member of the family expressed in the thyroid tissue, is involved in the morphogenesis of the gland and in the transcriptional regulation of thyroid-specific
Ana Rita Marques et al.
The Journal of clinical endocrinology and metabolism, 87(8), 3947-3952 (2002-08-06)
Recently, a translocation t(2;3)(q13;p25), leading to the formation of a chimeric PAX8-peroxisome proliferator-activated receptor (PPAR)gamma 1 oncogene, was detected in follicular thyroid carcinomas (FTC), but not in follicular thyroid adenomas (FTA), papillary thyroid carcinomas (PTC), or multinodular hyperplasias. However, previous
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