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Merck
CN
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文件

361593

Sigma-Aldrich

青蒿素

98%

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别名:
青蒿素
经验公式（希尔记法）:
C15H22O5
CAS号:
63968-64-9
分子量:
282.33
MDL编号:
MFCD00081057
UNSPSC代码:
12352205
PubChem化学物质编号:
57649481
NACRES:
NA.79

质量水平

100

检测方案

98%

形式

solid

旋光性

[α]20/D +76°, c = 0.5 in methanol

mp

156-157 °C (lit.)

抗生素抗菌谱

parasites
viruses

应用

metabolomics
vitamins, nutraceuticals, and natural products

作用机制

enzyme | inhibits

SMILES字符串

C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3OC4(C)CC[C@@H]1[C@@]23OO4

InChI

1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1

InChI key

BLUAFEHZUWYNDE-NNWCWBAJSA-N

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相关类别

一般描述

青蒿素是从青蒿（Artemisia annua）中提取得到的。它具有抗癌、 抗原虫和抗病毒活性。青蒿素与脑干脑病有关。

应用

青蒿素已可用于：
  • 药物敏感性测定
  • 作为对毛状根所含青蒿素进行定量的标准品
  • 通过3-(4,5-二甲基-2-噻唑)-2,5-二苯基溴化四氮唑（MTT）测定来检测细胞活力
  • 作为抗疟药，用于研究自噬相关（ATG）基因在恶性疟原虫（ P. falciparum ）无性和有性血液期的作用

生化/生理作用

青蒿素是一种倍半萜内酯，是一种高效的抗疟疾（恶性疟疾）药物。青蒿素也是一种能有效对抗血吸虫病的驱虫剂（寄生虫）。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. In what solvents is Product 361593, Artemisinin, soluble?

    According to the chemicals encyclopedia published by the Royal Society of Chemistry, artemisinin is expected to be soluble in most aprotic solvents and slightly soluble in oil. Sigma-Aldrich tests the solubility of this product in chloroform at 25 mg/mL. Our quality control is also able to prepare a 0.5% solution in methanol in order to measure the optical rotation.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections
Pillai DR, et al.
Malaria Journal, 11(1), 131-131 (2012)
Stimulation of artemisinin synthesis by combined cerebroside and nitric oxide elicitation in Artemisia annua hairy roots
Wang JW, et al.
Applied Microbiology and Biotechnology, 85(2), 285-292 (2009)
Pierre-Eric Campos et al.
Marine drugs, 17(3) (2019-03-17)
Chemical study of the CH₂Cl₂-MeOH (1:1) extract of the sponge Fascaplysinopsis reticulata collected in Mayotte highlighted three new tryptophan derived alkaloids, 6,6'-bis-(debromo)-gelliusine F (1), 6-bromo-8,1'-dihydro-isoplysin A (2) and 5,6-dibromo-8,1'-dihydro-isoplysin A (3), along with the synthetically known 8-oxo-tryptamine (4) and the
Olivo Miotto et al.
Nature genetics, 45(6), 648-655 (2013-04-30)
We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. Within this relatively small geographic area
The multifunctional autophagy pathway in the human malaria parasite, Plasmodium falciparum
Cervantes S, et al.
Autophagy, 10(1), 80-92 (2014)
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