biological source
mouse
conjugate
unconjugated
antibody form
diluted ascites fluid
antibody product type
primary antibodies
clone
G3, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (342M-14)
vial of 0.5 mL concentrate (342M-15)
bottle of 1.0 mL predilute (342M-17)
vial of 1.0 mL concentrate (342M-16)
bottle of 7.0 mL predilute (342M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200-1:1000
isotype
IgG1
control
uterus
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Gene Information
human ... TPSAB1(7177)
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
Tryptases constitute a subfamily of trypsin-like proteinases, stored in the mast cell secretory granules and basophils. Upon cellular activation, these enzymes are released into the extracellular environment. Anti-tryptase is a good marker for mast cells, basophils, and their derivatives.
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Tryptase Positive Control Slides, Product No. 342S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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J H Jordan et al.
Human pathology, 32(5), 545-552 (2001-06-19)
In an attempt to identify novel diagnostic markers for mast cell (MC)-proliferative disorders, serial bone marrow (bm) sections of 22 patients with mastocytosis (systemic indolent mastocytosis, n = 19; mast cell leukemia [MCL], n = 1; isolated bm mastocytosis, n
Andreas Chott et al.
The American journal of surgical pathology, 27(7), 1013-1019 (2003-06-27)
Mast cell sarcoma is an extremely rare and aggressive type of mast cell disease. Only a few cases have been described so far, and little is known about the biology and phenotype of afflicted cells. We describe morphologic and immunophenotypic
L K Gordon et al.
Clinical immunology (Orlando, Fla.), 94(1), 42-50 (1999-12-23)
pANCA is a marker antibody expressed in most patients with ulcerative colitis, and its cognate antigen is potentially an immunologic target in this disease. This study evaluates whether pANCA detects an autoantigen that is expressed in the colonic mucosa. Immunohistochemistry
C Y Li
Leukemia research, 25(7), 537-541 (2001-05-30)
The diagnosis of mastocytosis or mast cell disease may be difficult sometimes because of the wide variety of clinical presentation, abnormal morphology of mast cells, and variation in histologic features which may mimic varieties of other diseases. Over the years
Mikako Aoki et al.
International archives of allergy and immunology, 130(3), 216-223 (2003-03-28)
Basal cell carcinoma (BCC) is the most common malignant tumor of the skin. Although an increase in mast cell infiltration was observed in BCC lesions, definite evidence of an active role of mast cells in the pathogenesis of BCC is
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