所有图片(1)

文件

34025

双溴二胺

Name: 双溴二胺
Brand: SIGMA

BioReagent, suitable for fluorescence, ≥95.0% (CHN)

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₀H₁₀Br₂N₂O₂

CAS号:

68654-25-1

分子量:

350.01

Beilstein:

4189453

MDL编号:

MFCD00036952

UNSPSC代码:

12352108

PubChem化学物质编号:

57649022

NACRES:

NA.32

产品线

BioReagent

质量水平

100

检测方案

≥95.0% (CHN)

mp

170-172 °C (lit.)

溶解性

DMF: soluble
acetonitrile: soluble
chloroform: soluble

荧光

λ_ex 391 nm in methanol
λ_ex 393 nm; λ_em 477 nm in 0.1 M Tris pH 7.0, gutathione red

适用性

suitable for fluorescence

储存温度

2-8°C

SMILES字符串

CC1=C(CBr)N2N(C1=O)C(=O)C(C)=C2CBr

InChI

1S/C10H10Br2N2O2/c1-5-7(3-11)13-8(4-12)6(2)10(16)14(13)9(5)15/h3-4H2,1-2H3

InChI key

OSIYFMVMZXJKSP-UHFFFAOYSA-N

应用

Dibromobimane是一种双官能化硫醇试剂，用作半胱氨酸谱图和研究蛋白质结构/构象及交联过程的交联剂。

包装

无底玻璃瓶。内含物在插入的融合锥体内。

其他说明

荧光硫醇特异性标记试剂

象形图

GHS07

警示用语：

Warning

危险声明

H315,H319,H335

预防措施声明

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Molecular mechanism for lateral lipid diffusion between the outer membrane external leaflet and a beta-barrel hydrocarbon ruler.

M Adil Khan et al.

Biochemistry, 48(41), 9745-9756 (2009-09-23)

Membrane-intrinsic enzymes are embedded in lipids, yet how such enzymes interrogate lipid substrates remains a largely unexplored fundamental question. The outer membrane phospholipid:lipid A palmitoyltransferase PagP combats host immune defenses during infection and selects a palmitate chain using its beta-barrel

Cyclopentenone prostaglandins with dienone structure promote cross-linking of the chemoresistance-inducing enzyme glutathione transferase P1-1.

Francisco J Sánchez-Gómez et al.

Molecular pharmacology, 78(4), 723-733 (2010-07-16)

Glutathione transferase P1-1 (GSTP1-1) plays crucial roles in cancer chemoprevention and chemoresistance and is a key target for anticancer drug development. Oxidative stress or inhibitor-induced GSTP1-1 oligomerization leads to the activation of stress cascades and apoptosis in various tumor cells.

Identification of residues in the drug-binding site of human P-glycoprotein using a thiol-reactive substrate.

T W Loo et al.

The Journal of biological chemistry, 272(51), 31945-31948 (1998-01-24)

We identified a thiol-reactive compound, dibromobimane (dBBn), that was a potent stimulator (8.2-fold) of the ATPase activity of Cys-less P-glycoprotein. We then used this compound together with cysteine-scanning mutagenesis to identify residues in transmembrane segment (TM) 6 and TM12 that

Conformational changes in a pore-forming region underlie voltage-dependent "loop gating" of an unapposed connexin hemichannel.

Qingxiu Tang et al.

The Journal of general physiology, 133(6), 555-570 (2009-05-27)

The structure of the pore is critical to understanding the molecular mechanisms underlying selective permeation and voltage-dependent gating of channels formed by the connexin gene family. Here, we describe a portion of the pore structure of unapposed hemichannels formed by

Identification of residues within the drug-binding domain of the human multidrug resistance P-glycoprotein by cysteine-scanning mutagenesis and reaction with dibromobimane.