34025
双溴二胺
BioReagent, suitable for fluorescence, ≥95.0% (CHN)
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C10H10Br2N2O2
化学文摘社编号:
分子量:
350.01
UNSPSC Code:
12352108
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4189453
InChI
1S/C10H10Br2N2O2/c1-5-7(3-11)13-8(4-12)6(2)10(16)14(13)9(5)15/h3-4H2,1-2H3
SMILES string
CC1=C(CBr)N2N(C1=O)C(=O)C(C)=C2CBr
InChI key
OSIYFMVMZXJKSP-UHFFFAOYSA-N
product line
BioReagent
assay
≥95.0% (CHN)
Quality Level
solubility
DMF: soluble, acetonitrile: soluble, chloroform: soluble
fluorescence
λex 391 nm in methanol, λex 393 nm; λem 477 nm in 0.1 M Tris pH 7.0, gutathione red
suitability
suitable for fluorescence
storage temp.
2-8°C
Application
Dibromobimane是一种双官能化硫醇试剂，用作半胱氨酸谱图和研究蛋白质结构/构象及交联过程的交联剂。
Packaging
无底玻璃瓶。内含物在插入的融合锥体内。
Other Notes
荧光硫醇特异性标记试剂
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
T W Loo et al.
The Journal of biological chemistry, 275(50), 39272-39278 (2000-10-03)
P-glycoprotein (P-gp) can transport a wide variety of cytotoxic compounds that have diverse structures. Therefore, the drug-binding domain of the human multidrug resistance P-gp likely consists of residues from multiple transmembrane (TM) segments. In this study, we completed cysteine-scanning mutagenesis
M Adil Khan et al.
Biochemistry, 48(41), 9745-9756 (2009-09-23)
Membrane-intrinsic enzymes are embedded in lipids, yet how such enzymes interrogate lipid substrates remains a largely unexplored fundamental question. The outer membrane phospholipid:lipid A palmitoyltransferase PagP combats host immune defenses during infection and selects a palmitate chain using its beta-barrel
Francisco J Sánchez-Gómez et al.
Molecular pharmacology, 78(4), 723-733 (2010-07-16)
Glutathione transferase P1-1 (GSTP1-1) plays crucial roles in cancer chemoprevention and chemoresistance and is a key target for anticancer drug development. Oxidative stress or inhibitor-induced GSTP1-1 oligomerization leads to the activation of stress cascades and apoptosis in various tumor cells.
T W Loo et al.
The Journal of biological chemistry, 272(51), 31945-31948 (1998-01-24)
We identified a thiol-reactive compound, dibromobimane (dBBn), that was a potent stimulator (8.2-fold) of the ATPase activity of Cys-less P-glycoprotein. We then used this compound together with cysteine-scanning mutagenesis to identify residues in transmembrane segment (TM) 6 and TM12 that
Qingxiu Tang et al.
The Journal of general physiology, 133(6), 555-570 (2009-05-27)
The structure of the pore is critical to understanding the molecular mechanisms underlying selective permeation and voltage-dependent gating of channels formed by the connexin gene family. Here, we describe a portion of the pore structure of unapposed hemichannels formed by
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持