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Merck
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主要文件

安全信息

315R-1

Sigma-Aldrich

PD-1 (EP239) Rabbit Monoclonal Primary Antibody

别名:

CD279, PD1, PDCD1, SLEB2, hPH-1, hSLE1, programmed cell death 1, programmed cell death protein 1, protein PD-1, systemic lupus erythematosus suseptibilitl 2

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP239, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (315R-14)
vial of 0.1 mL concentrate Research Use Only (315R-14-RUO)
vial of 0.5 mL concentrate (315R-15)
vial of 1.0 mL concentrate (315R-16)
vial of 1.0 mL concentrate Research Use Only (315R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (315R-17-RUO)
vial of 1.0 mL predilute ready-to-use (315R-17)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (315R-18-RUO)
vial of 7.0 mL predilute ready-to-use (315R-18)

制造商/商品名称

Cell Marque®

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

同位素/亚型

IgG

控制

lymph node, tonsil

运输

wet ice

储存温度

2-8°C

可视化

cytoplasmic, membranous

基因信息

human ... PDCD1(5133)

一般描述

Programmed death-1 (PD-1) is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PD-1 is expressed by few B-cells, so anti-PD-1 may be a more specific and useful marker in the identification of angioimmunoblastic lymphoma. In addition, PD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells. PD-1 expression in angioimmunoblastic lymphoma lends further support to this model of T-cell oncogenesis, in which specific subtypes of T-cells may undergo neoplastic transformation and result in specific distinct histologic, immunophenotypic, and clinical subtypes of T-cell neoplasia.

质量

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

联系

PD-1 Positive Control Slides, Product No. 315S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Predilute: diluted in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Concentrate: diluted in Phosphate Buffered Saline, pH 7.2, with 1% BSA and <0.1% Sodium Azide

制备说明

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000389583
0000389577
0000389589
0000357524
0000357526

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访问文档库

Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjogren's syndrome.
Kobayashi M, Kawano S, Hatachi S, et al.
The Journal of Rheumatology, 32(11), 2156-2163 (2005)
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer.
Hamanishi J, Mandai M, Iwasaki M, et al.
Proceedings of the National Academy of Sciences of the USA, 104(9), 3360-3365 (2007)
David M Dorfman et al.
The American journal of surgical pathology, 30(7), 802-810 (2006-07-05)
Programmed death-1 (PD-1), a member of the CD28 costimulatory receptor family, is expressed by germinal center-associated T cells in reactive lymphoid tissue. In a study of a wide range of lymphoproliferative disorders, neoplastic T cells in 23 cases of angioimmunoblastic
Yoshiko Iwai et al.
Immunology letters, 83(3), 215-220 (2002-07-04)
PD-1 is an immunoinhibitory receptor, which belongs structurally to the CD28 family. PD-1-deficient mice show breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. We previously described expression of PD-1 on activated T and B lymphocytes and myeloid cells. However
Anne Isine Bolstad et al.
Arthritis and rheumatism, 48(1), 174-185 (2003-01-16)
To assess salivary gland tissues obtained from patients with primary Sjögren's syndrome (SS) for the gene expression profile of the candidate genes TNFRSF6 (Fas), TNFSF6 (FasL), SSA1 (Ro52 alpha and the splice variant Ro52 beta), SSB (La), CTLA4, PDCD1 (PD-1)
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