推荐产品
生物来源
rabbit
质量水平
100
500
偶联物
unconjugated
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
SP34, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
形式
buffered aqueous solution
种属反应性
human
包装
vial of 0.1 mL concentrate (312R-14)
vial of 0.5 mL concentrate (312R-15)
bottle of 1.0 mL predilute (312R-17)
vial of 1.0 mL concentrate (312R-16)
bottle of 7.0 mL predilute (312R-18)
制造商/商品名称
Cell Marque™
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
同位素/亚型
IgG
控制
tonsil
运输
wet ice
储存温度
2-8°C
可视化
nuclear
基因信息
human ... PAX5(5079)
一般描述
PAX-5 encodes for B-cell-specific activator protein (BSAP), a marker for B-cells, including B-lymphoblastic neoplasms and maturation stage. It is found in most cases of mature and precursor B-cell non-Hodgkin′s lymphomas/leukemias. In approximately 97% of cases of classic Hodgkin′s lymphoma, Reed-Sternberg cells express PAX-5. PAX-5 is not detected in multiple myeloma and solitary plasmacytoma, making it useful for such differentiation. Diffuse large B-cell lymphomas do express PAX-5 save for those with terminal B-cell differentiation. T-cell neoplasms do not stain with anti-PAX-5. There is a strong association with CD20 expression.
质量
 IVD |  IVD |  IVD |  RUO |
联系
PAX-5 Positive Control Slides, Product No. 312S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
制备说明
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
法规信息
监管及禁止进口产品
Ines Schwering et al.
Blood, 101(4), 1505-1512 (2002-10-24)
Hodgkin and Reed-Sternberg (HRS) cells represent the malignant cells in classical Hodgkin lymphoma (HL). Because their immunophenotype cannot be attributed to any normal cell of the hematopoietic lineage, the origin of HRS cells has been controversially discussed, but molecular studies
Brunangelo Falini et al.
Blood, 99(2), 409-426 (2002-01-10)
Acquired chromosomal anomalies (most commonly translocations) in lymphoma and leukemia usually result in either activation of a quiescent gene (by means of immunoglobulin or T-cell-receptor promotors) and expression of an intact protein product, or creation of a fusion gene encoding
Emina Torlakovic et al.
The American journal of surgical pathology, 26(10), 1343-1350 (2002-10-03)
Whereas L26 (anti-CD20) is well established as a B-cell marker of high specificity for use in paraffin-embedded tissues and JCB117 (anti-CD79a) is increasingly used, a comparable additional pan-B-cell antibody has hitherto not yet been identified. Here we have studied the
Klaus Willenbrock et al.
Laboratory investigation; a journal of technical methods and pathology, 82(9), 1103-1109 (2002-09-10)
The atypical cells of CD30(+) cutaneous lymphoproliferative disorders (CD30CLD) are commonly of T-cell origin and frequently have a similar morphology as Hodgkin or Reed-Sternberg cells of Hodgkin's lymphoma (HL). HL is one of the tumors associated with CD30CLD. Although most
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