30891
胆绿素 盐酸盐
≥97.0% (TLC)
别名:
胆绿素
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关于此项目
经验公式（希尔记法）:
C33H34N4O6 · HCl
化学文摘社编号:
分子量:
619.11
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
产品名称
胆绿素 盐酸盐, ≥97.0% (TLC)
SMILES string
Cl.CC1=C(C=C)C(\NC1=O)=C\c2[nH]c(/C=C3\N=C(\C=C4/NC(=O)C(C=C)=C4C)C(C)=C3CCC(O)=O)c(CCC(O)=O)c2C
InChI
1S/C33H34N4O6.ClH/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26;/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41);1H/b26-13-,27-14-,28-15-;
InChI key
KTRFJVRKVQROKS-UJCZHUFNSA-N
assay
≥97.0% (TLC)
form
powder or crystals
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
Quality Level
Application
胆绿素盐酸盐已：
- 用于处理J774A.1细胞，以研究其在β (β)-内啡肽水平变化中的作用
- 作为商业标准品，使用气相色谱-质谱分析法(GC-MS)检测小鼠不稳定和稳定斑块组织中的胆绿素
- 添加含Fucci细胞以改进mIFP信号
- 在一些视网膜制剂中检测对红外荧光蛋白(iRFP)的影响
Biochem/physiol Actions
胆绿素(BV)是一种优秀的抗炎剂，可抵御脂多糖(LPS)诱导的小鼠内皮细胞肺损伤。它有助于保护多微生物败血症。胆绿素对大鼠肝脏有细胞保护作用，对长期缺血再灌注损伤有保护作用。它还显示出抗氧化活性。
General description
胆绿素（BV）被认为是内源性近红外（NIR）吸收色素。 它是血红素降解（血红素分解代谢）为胆红素的线性四吡咯中间体。两栖类和鸟类的胆汁只含胆绿素，不含胆红素。
Packaging
无底玻璃瓶。内含物在插入的融合锥体内。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Marking cells with infrared fluorescent proteins to preserve photoresponsiveness in the retina
Fyk-Kolodziej B, et al.
Biotechniques, 57(5), 245-253 (2014)
Elin Claesson et al.
eLife, 9 (2020-04-02)
Phytochrome proteins control the growth, reproduction, and photosynthesis of plants, fungi, and bacteria. Light is detected by a bilin cofactor, but it remains elusive how this leads to activation of the protein through structural changes. We present serial femtosecond X-ray
Marcus Overhaus et al.
American journal of physiology. Gastrointestinal and liver physiology, 290(4), G695-G703 (2006-03-16)
Highly inducible heme oxygenase (HO)-1 is protective against acute and chronic inflammation. HO-1 generates carbon monoxide (CO), ferrous iron, and biliverdin. The aim of this study was to investigate the protective effects of biliverdin against sepsis-induced inflammation and intestinal dysmotility.
T Yoshida et al.
Journal of inorganic biochemistry, 82(1-4), 33-41 (2001-01-02)
Heme oxygenase catalyzes the three step-wise oxidation of hemin to alpha-biliverdin, via alpha-meso-hydroxyhemin, verdoheme, and ferric iron-biliverdin complex. This enzyme is a simple protein which does not have any prosthetic groups. However, heme and its two metabolites, alpha-meso-hydroxyhemin and verdoheme
Biliverdin in biological systems
Cornelius, C. E. et al.
One Medicine: A Tribute to Kurt Benirschkle, 321-334 (1984)
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