biological source
synthetic
Quality Level
form
powder
potency
≥900 μg per mg
color
white to off-white
mp
147 °C (dec.) (lit.)
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycobacteria
mode of action
cell wall synthesis | interferes
storage temp.
−20°C
SMILES string
N[C@@H]1CONC1=O
InChI
1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
InChI key
DYDCUQKUCUHJBH-UWTATZPHSA-N
General description
Chemical structure: amino acid derivatives
Application
D-Cycloserine acts as inhibitor of various enzymes.
Biochem/physiol Actions
作用方式:抑制细胞壁生物合成(D-Ala 肽键形成)。同时可防止将D-Ala转化为L-Ala。抑菌性。
作用于 NMDA 谷氨酸能受体的甘氨酸调节位点的部分激动剂;抗革兰氏阴性细菌的抗生素。
干预方式:D-Ala转运干预。
作用于 NMDA 谷氨酸能受体的甘氨酸调节位点的部分激动剂;抗革兰氏阴性细菌的抗生素。
干预方式:D-Ala转运干预。
Mode of Action: Inhibits cell wall biosynthesis (D-Ala peptide bond formation). Also prevents conversion of D-Ala to L-Ala. Bacteriostatic. Mode of Resistance: D-Ala transport interference.
Packaging
1g, 5g, 25g
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Air sensitive. Keep in a dry place.
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Simon P Byrne et al.
Depression and anxiety, 32(6), 408-414 (2015-03-17)
For exposure therapy to be successful, it is essential that fear extinction learning extends beyond the treatment setting. D-cycloserine (DCS) may facilitate treatment gains by increasing generalization of extinction learning, however, its effects have not been tested in children. We
Marta Portero-Tresserra et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 24(11), 1798-1807 (2014-12-03)
Previous research has demonstrated that systemic D-cycloserine (DCS), a partial agonist of the N-methyl-D-aspartate receptor (NMDAR), enhances memory processes in different learning paradigms and attenuates mnemonic deficits produced by diverse pharmacological manipulations. In the present study two experiments were conducted
M.K. Jain
Handbook of Enzyme Inhibitors, 112-112 (1982)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 30020-25G | 04061835541225 |
| 30020-5G | 04061835517886 |
| 30020-1G | 04061835541218 |