27883
香豆雌酚
BioReagent, suitable for fluorescence, ≥97.5% (HPLC)
别名:
7,12-苯二羟基香豆素
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关于此项目
经验公式（希尔记法）:
C15H8O5
化学文摘社编号:
分子量:
268.22
UNSPSC Code:
41116107
NACRES:
NA.77
PubChem Substance ID:
EC Number:
207-525-6
Beilstein/REAXYS Number:
266702
MDL number:
InChI key
ZZIALNLLNHEQPJ-UHFFFAOYSA-N
InChI
1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H
SMILES string
Oc1ccc-2c(OC(=O)c3c-2oc4cc(O)ccc34)c1
product line
BioReagent
assay
≥97.5% (HPLC)
form
powder
mp
≥350 °C (lit.)
solubility
DMSO: soluble
fluorescence
λex 377 nm; λem 437 nm in 0.1 M Tris pH 8.0
suitability
suitable for fluorescence
Quality Level
Gene Information
human ... ESR1(2099), ESR2(2100)
mouse ... Esr1(13982)
rat ... Ar(24208)
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Biochem/physiol Actions
香豆酚通过雌激素受体-α的介导而对大脑和垂体具有抗雌激素作用。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Hae-In Lee et al.
Applied and environmental microbiology, 78(8), 2896-2903 (2012-02-07)
Flavonoids, secondary plant metabolites which mainly have a polyphenolic structure, play an important role in plant-microbe communications for nitrogen-fixing symbiosis. Among 10 polyphenolic compounds isolated from soybean roots in our previous study, coumestrol showed the highest antioxidant activity. In this
Ellen B Gold et al.
Menopause (New York, N.Y.), 20(3), 305-314 (2013-02-26)
Although reduction of vasomotor symptoms (VMS; hot flashes and night sweats) has been reported in postmenopausal women who used isoflavones, a clear dose response has not been shown, has largely not been reported for perimenopausal women, and has largely only
Sahar Karieb et al.
The British journal of nutrition, 108(10), 1736-1745 (2012-02-01)
Osteoblast and osteoclast activity is disrupted in post-menopausal osteoporosis. Thus, to fully address this imbalance, therapies should reduce bone resorption and promote bone formation. Dietary factors such as phyto-oestrogens and Zn have beneficial effects on osteoblast and osteoclast activity. However
Suzan L Carmichael et al.
Nutrition journal, 10, 105-105 (2011-10-08)
Phytoestrogens may be associated with a variety of different health outcomes, including outcomes related to reproductive health. Recently published data on phytoestrogen content of a wide range of foods provide an opportunity to improve estimation of dietary phytoestrogen intake. Using
Gail A Greendale et al.
Menopause (New York, N.Y.), 19(8), 894-903 (2012-03-15)
Phytoestrogens, which consist mainly of isoflavones, lignans, and coumestans have estrogenic and anti-inflammatory properties. Previous research suggests that higher dietary or supplemental intakes of isoflavones and lignans are related to better cognitive performance in middle-aged and older women. We conducted
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