27883
香豆雌酚
BioReagent, suitable for fluorescence, ≥97.5% (HPLC)
别名:
7,12-苯二羟基香豆素
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关于此项目
经验公式（希尔记法）:
C15H8O5
化学文摘社编号:
分子量:
268.22
UNSPSC Code:
41116107
NACRES:
NA.77
PubChem Substance ID:
EC Number:
207-525-6
Beilstein/REAXYS Number:
266702
MDL number:
产品名称
香豆雌酚, BioReagent, suitable for fluorescence, ≥97.5% (HPLC)
InChI key
ZZIALNLLNHEQPJ-UHFFFAOYSA-N
InChI
1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H
SMILES string
Oc1ccc-2c(OC(=O)c3c-2oc4cc(O)ccc34)c1
product line
BioReagent
assay
≥97.5% (HPLC)
form
powder
mp
≥350 °C (lit.)
solubility
DMSO: soluble
fluorescence
λex 377 nm; λem 437 nm in 0.1 M Tris pH 8.0
suitability
suitable for fluorescence
Quality Level
Gene Information
human ... ESR1(2099), ESR2(2100)
mouse ... Esr1(13982)
rat ... Ar(24208)
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Biochem/physiol Actions
香豆酚通过雌激素受体-α的介导而对大脑和垂体具有抗雌激素作用。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Elisa V Bandera et al.
BMC women's health, 11, 40-40 (2011-09-29)
While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention. We conducted a population-based case-control study to evaluate phytoestrogen intake from foods and supplements and epithelial
Corinne C Hoerger et al.
Journal of agricultural and food chemistry, 59(3), 847-856 (2011-01-06)
We developed and validated three different sample preparation and extraction methods followed by HPLC-MS/MS (negative electrospray ionization) analysis for the quantification of estrogenic isoflavones (formononetin, daidzein, equol, biochanin A, and genistein) and coumestrol in red clover, soil, and manure. Plant
Sarah J Lowry et al.
Nutrition and cancer, 64(6), 783-789 (2012-08-07)
Some forms of estrogen are associated with breast cancer risk as well as with mammographic density (MD), a strong marker of breast cancer risk. Whether phytoestrogen intake affects breast density, however, remains unclear. We evaluated the association between serum levels
Man-Hai Liu et al.
Neurological research, 33(6), 663-672 (2011-06-29)
Estrogen replacement therapy can decrease the risk of developing Alzheimer's disease. Phytoestrogens have been proposed as potential alternatives to estrogen replacement therapy. The purpose of this study was to evaluate the in vitro protective effects of coumestrol on mice astrocytes.
Alberto Cassetta et al.
The Biochemical journal, 441(1), 151-160 (2011-09-21)
The 17β-HSD (17β-hydroxysteroid dehydrogenase) from the filamentous fungus Cochliobolus lunatus (17β-HSDcl) is a NADP(H)-dependent enzyme that preferentially catalyses the interconversion of inactive 17-oxo-steroids and their active 17β-hydroxy counterparts. 17β-HSDcl belongs to the SDR (short-chain dehydrogenase/reductase) superfamily. It is currently the
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