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Merck
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安全信息

275R-3

Sigma-Aldrich

Ki-67 (MRQ-64) Rabbit Monoclonal Antibody

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UNSPSC代码:
12352203

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

MRQ-64, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形式

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (275R-34)
vial of 0.1 mL concentrate Research Use Only (275R-34-RUO)
vial of 0.5 mL concentrate (275R-35)
vial of 1.0 mL concentrate (275R-36)
vial of 1.0 mL concentrate Research Use Only (275R-36-RUO)
vial of 1.0 mL pre-dilute Research Use Only (275R-37-RUO)
vial of 1.0 mL pre-dilute ready-to-use (275R-37)
vial of 25.0 mL pre-dilute ready-to-use (275R-30)
vial of 25.0 mL pre-dilute ready-to-use Research Use Only (275R-30-RUO)
vial of 7.0 mL pre-dilute ready-to-use (275R-38)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (275R-38-RUO)

制造商/商品名称

Cell Marque™

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同位素/亚型

IgG

控制

Burkitt lymphoma, breast (ductl carcinoma in situ), tonsil

运输

wet ice

储存温度

2-8°C

可视化

nuclear

基因信息

human ... MKI67(4288)

相关类别

一般描述

Ki-67 (MRQ-64) is an antibody designed to target Ki-67 antigen-a nuclear protein encoded by the MKI67 gene whose presence correlates with G1, S, G2, and the mitotic phases of the cell cycle.1 Though its specific role is largely postulated and still yet to be determined, Ki-67′s presence during cellular division makes it an excellent target for labeling rapidly growing malignancies.2 Given that its presence correlates with cell proliferation, the immunohistochemical labeling of Ki-67 antigen may be useful in characterizing a lesion′s growth fraction. It has been demonstrated that identifying this antigen by IHC is useful in characterizing lesions of the breast, lymphoid cells, astrocytes, and uterus.3-9

质量

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

联系

Ki-67 Positive Control Slides, Product No. 275S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

Download the IFU specific to your product lot and format
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Note: This IFU may not apply to your specific product lot.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

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Xiaoming Sun et al.
Chromosoma, 127(2), 175-186 (2018-01-13)
Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become better understood. Ki-67 has roles in both interphase and mitotic cells, and
Nandish Vastrad Shivaprasad et al.
Journal of neurosciences in rural practice, 7(4), 510-514 (2016-10-04)
Astrocytomas are the most common primary tumor of the central nervous system. The distinction between different tumor grades can be tested despite criteria given by the World Health Organization (WHO). Ki-67 is a potent biological marker used in grading of
Klaus Mayerhofer et al.
Acta obstetricia et gynecologica Scandinavica, 83(11), 1085-1088 (2004-10-19)
The aim of the current study was to evaluate the expression of Ki-67 in uterine smooth muscle tumors, comparing leiomyomas, uterine smooth muscle tumors of uncertain malignant potential (STUMP) and uterine leiomyosarcomas (LMS) and to prove the accuracy of a
Adi Broyde et al.
American journal of hematology, 84(6), 338-343 (2009-04-23)
Expression of Ki-67, a nuclear antigen protein present in all cycling cells, is used to determine the growth fraction of tumors. The aim of this study was to evaluate the role and prognostic significance of the Ki-67 proliferation index (PI)
E C Inwald et al.
Breast cancer research and treatment, 139(2), 539-552 (2013-05-16)
The proliferation marker Ki-67 is one of the most controversially discussed parameters for treatment decisions in breast cancer patients. The purpose of this study was to evaluate the routine use and value of Ki-67 as a prognostic marker, and to
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