推荐产品
生物来源
rabbit
质量水平
100
500
偶联物
unconjugated
抗体形式
Ig fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
形式
buffered aqueous solution
种属反应性
human
包装
vial of 0.1 mL concentrate (262A-14)
vial of 0.5 mL concentrate (262A-15)
bottle of 1.0 mL predilute (262A-17)
vial of 1.0 mL concentrate (262A-16)
bottle of 7.0 mL predilute (262A-18)
制造商/商品名称
Cell Marque™
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
控制
ALCL, spleen
运输
wet ice
储存温度
2-8°C
可视化
cytoplasmic
基因信息
human ... GZMB(3002)
一般描述
Granzymes are serine proteases which are stored in specialized lytic granules of cytotoxic T-lymphocytes and in natural killer cells. Anti-granzyme B has been useful in diagnosing natural killer/T-cell lymphoma, as well as anaplastic large cell lymphoma. High percentages of cytotoxic T-cells have been shown to be an unfavorable indicator in Hodgkin disease.
质量
 IVD |  IVD |  IVD |  RUO |
联系
Granzyme B Positive Control Slides, Product No. 262S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
制备说明
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
法规信息
监管及禁止进口产品
J J Oudejans et al.
Blood, 89(4), 1376-1382 (1997-02-15)
Although the results of treatment of Hodgkin's disease (HD) have improved considerably in the last decades, the disease remains fatal in a minority of patients. We have recently shown that numbers of activated cytotoxic T cells (CTLs), present in tumor
J A Kummer et al.
Clinical and experimental immunology, 100(1), 164-172 (1995-04-01)
Cytoplasmic granules from activated natural killer (NK) and cytotoxic T lymphocytes (CTL) contain a pore-forming protein, perforin, and several homologous serine proteinases called granzymes. Expression of these proteins correlates with the cytolytic potential of cytotoxic lymphocytes. Using a panel of
Naoko Kato et al.
The American Journal of dermatopathology, 25(2), 142-147 (2003-03-26)
A neutrophil-rich anaplastic large cell lymphoma (ALCL) presented in the skin of a 47-year-old Japanese woman. The solitary cutaneous lesion was an eroded, 10-mm, dome-shaped nodule involving the skin of her left upper arm. Histologically, it showed a proliferation of
J J Oudejans et al.
The American journal of pathology, 148(1), 233-240 (1996-01-01)
Reed-Sternberg (RS) and Hodgkin's (H) cells are considered to be the neoplastic cells in Hodgkin's disease. Although most data suggest a lymphoid origin, the nature of these cells still remains the subject of considerable controversy. Recently, monoclonal antibodies became available
Jie Liu et al.
The Journal of dermatology, 30(10), 735-741 (2003-12-20)
Nasal natural killer (NK)/T cell lymphoma is an Epstein-Barr virus (EBV) associated lymphoma that arises in the nasal area and aggressively invades surrounding tissues. Our patient was a 48-year-old male who had had nasal obstruction and nasal discharge for 2
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