推荐产品
生物来源
mouse
质量水平
100
500
偶联物
unconjugated
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
1G12, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
形式
buffered aqueous solution
种属反应性
human
包装
vial of 0.1 mL concentrate (261M-94)
vial of 0.5 mL concentrate (261M-95)
bottle of 1.0 mL predilute (261M-97)
vial of 1.0 mL concentrate (261M-96)
bottle of 7.0 mL predilute (261M-98)
制造商/商品名称
Cell Marque™
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
同位素/亚型
IgG1
控制
hepatocellular carcinoma (HCC)
运输
wet ice
储存温度
2-8°C
可视化
cytoplasmic
基因信息
human ... GPC3(2719)
一般描述
磷脂酰肌醇蛋白聚糖3（GPC3）是一种膜结合硫酸肝素蛋白聚糖，可参与细胞生长和分化。GPC3的表达见于大多数肝细胞癌（HCC），但是在非肿瘤肝组织中非常少见，这使其成为有用的HCC标记物。此外，这种标记物在许多卵黄囊瘤中表达。
质量
 IVD |  IVD |  IVD | RUO |
联系
磷脂酰肌醇聚糖-3阳性对照玻片，产品编号261S，可用于免疫组化（福尔马林固定、石蜡包埋的切片）。
外形
溶于Tris缓冲液中的溶液（pH 7.3-7.7），含1％BSA和 <0.1％叠氮化钠
制备说明
下载针对您的产品批次和规格的使用说明书(IFU)注意：该过程需要可在包装或产品标签上找到的密钥代码。
其他说明
有关技术服务，请联系： 800-665-7284或电子邮件：service@cellmarque.com
法律信息
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
法规信息
监管及禁止进口产品
Debra L Zynger et al.
The American journal of surgical pathology, 30(12), 1570-1575 (2006-11-24)
Glypican 3 (GPC3), a membrane-bound heparin sulfate proteoglycan, may play a role in promoting embryonic cell growth and differentiation. GPC3 is mutated in Simpson-Golabi-Behmel syndrome, characterized by tissue overgrowth and an increased risk of embryonal malignancies. Recently, GPC3 was reported
Dina Kandil et al.
Cancer, 111(5), 316-322 (2007-09-01)
Glypican-3 (GPC3) is a heparan sulfate proteoglycan which is elevated in the serum of patients with hepatocellular carcinoma (HCC), but not in healthy blood donors, or patients with benign liver disease. GPC3 immunohistochemistry (IHC) is a promising marker of HCC
Wanda M P Coston et al.
The American journal of surgical pathology, 32(3), 433-444 (2008-02-28)
Distinguishing a well-differentiated hepatocellular carcinoma (HCC) from normal and cirrhotic liver tissue or benign liver nodules, such as hepatic adenoma (HA) and focal nodular hyperplasia (FNH), may be very difficult in some cases, particularly in small needle core biopsies. We
Debra L Zynger et al.
Human pathology, 39(2), 224-230 (2007-10-24)
Glypican 3 is a heparin sulfate proteoglycan bound to the cell surface that is theorized to participate in cell signaling, resulting in embryonic cell growth and differentiation. The GPC3 gene is mutated in Simpson-Golabi-Behmel syndrome, whose features include numerous developmental
Dina H Kandil et al.
Advances in anatomic pathology, 16(2), 125-129 (2009-06-25)
Glypican-3 (GPC3) is a heparan sulfate proteoglycan that plays an important role in cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal
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