258024
α-生育酚
≥95.5%
别名:
(±)-α-生育酚, DL-全-rac-α-生育酚, 维生素E
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关于此项目
经验公式（希尔记法）:
C29H50O2
化学文摘社编号:
分子量:
430.71
NACRES:
NA.28
PubChem Substance ID:
eCl@ss:
34058016
UNSPSC Code:
12352205
EC Number:
233-466-0
MDL number:
Beilstein/REAXYS Number:
94012
产品名称
α-生育酚, ≥95.5%
InChI key
GVJHHUAWPYXKBD-UHFFFAOYSA-N
InChI
1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
SMILES string
CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1
biological source
synthetic
assay
≥95.5%
form
liquid
technique(s)
HPLC: suitable
color
faint brown to brown
yellow to very dark yellow
density
0.950 g/mL at 20 °C (lit.)
application(s)
cell analysis
storage temp.
2-8°C
Quality Level
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Application
α-生育酚用于：
- 作为反相高效液相色谱法测定其浓度的标准品
- 研究其对二氧化氯（ClO2）细胞毒性的拯救作用
- 评估其对对乙酰氨基酚（APAP）介导的肝损伤的保护作用
Biochem/physiol Actions
生育酚（TCP）（维生素E）是一系列（α、β、γ和δ）手性有机分子，其色原烷醇环苯酚部分的甲基化程度不同。 生育酚是脂溶性抗氧化剂，可保护细胞膜免受氧化损伤。α-生育酚是人类优先吸收的生育酚形式。 生育酚的各种异构体和类似物在体内具有相反和不同的调节活性。
General description
α-生育酚是维生素E的活性形式。它起着氢过氧自由基清除剂的作用，可保护机体免受氧化损伤。α-生育酚在细胞信号传导和调节免疫应答中起关键作用。α-生育酚缺乏与无β脂蛋白血症、囊性纤维化和乳糜泻有关。它具有抗增殖作用。它抑制亚砷酸盐诱导的人成纤维细胞损伤。
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 1
ppe
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商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。
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