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About This Item
线性分子式:
ClHgC6H4CO2H
CAS号:
分子量:
357.16
Beilstein:
3662892
EC 号:
MDL编号:
UNSPSC代码:
12352202
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描述
cysteine active site modifier
方案
≥96.0% (Hg)
mp
287 °C (dec.) (lit.)
SMILES字符串
OC(=O)c1ccc([Hg]Cl)cc1
InChI
1S/C7H5O2.ClH.Hg/c8-7(9)6-4-2-1-3-5-6;;/h2-5H,(H,8,9);1H;/q;;+1/p-1
InChI key
YFZOUMNUDGGHIW-UHFFFAOYSA-M
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应用
Can be used to inhibit some enzymes that require unmodified cysteine residues (e.g., adenylyl cyclase).
其他说明
For the preparation of 4-hydroxymercuriobenzoate by neutralisation (appeared mistakenly as p-chloromercuriobenzoate, PCMB in earlier literature). Modifies mercapto groups in proteins, can be used for their determination
法规信息
新产品
Gabriela Galicia-Vázquez et al.
Analytical biochemistry, 384(1), 180-188 (2008-10-18)
Protein-RNA interactions are involved in all facets of RNA biology. The identification of small molecules that selectively block such bimolecular interactions could provide insight into previously unexplored steps of gene regulation. Such is the case for regulation of eukaryotic protein
The role of sulfhydryl groups in functioning of components of adenylate cyclase signal system in smooth muscles of the mollusk Anodonta cygnea (effect of N-ethylmaleimide and p-chloromercuribenzoic acid)
Shpakov A.O., and Derkach, K.V.
Tsitologia, 41, 499-505 (1999)
M C de Castillo et al.
Revista latinoamericana de microbiologia, 43(2), 70-75 (2006-10-26)
beta-Lactamase was isolated from Neisseria gonorrhoeae, obtained from male patients with gonococcic urethritis. Biochemical properties of the enzyme were studied. The enzyme was purified 38-fold by ammonium sulphate precipitation and using Sephadex G75 and DEAE-cellulose columns. The purified extract exhibited
Vardan T Karamyan et al.
European journal of pharmacology, 590(1-3), 87-92 (2008-06-24)
In the present study the existence of a non-AT(1), non-AT(2) angiotensin (Ang) binding site unmasked by the organomercurial protease inhibitor p-chloromercuribenzoate (PCMB) was demonstrated in mouse brain membranes, consistent with observations previously reported in the rat (Karamyan and Speth, 2007b).
P.D. Boyer
Journal of the American Chemical Society, 76, 4331-4331 (1954)
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