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Merck
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主要文件

安全信息

244R-1

Sigma-Aldrich

DOG1 (SP31) Rabbit Monoclonal Antibody

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

SP31, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (244R-14)
vial of 0.5 mL concentrate (244R-15)
bottle of 1.0 mL predilute (244R-17)
vial of 1.0 mL concentrate (244R-16)
bottle of 7.0 mL predilute (244R-18)

制造商/商品名称

Cell Marque®

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

同位素/亚型

IgG

控制

GIST

运输

wet ice

储存温度

2-8°C

可视化

cytoplasmic, membranous

基因信息

human ... ANO1(55107)

一般描述

DOG1 is a calcium-dependent chloride channel protein that is encoded by a gene called TMEM16A (TMEM16 FLJ10261, ANO1, ORAOV2, and AOS2) located on chromosome 11q13. DOG1 has many significant functions such as regulation of the cholinergic activity of gastrointestinal smooth muscle and regulation of both the survival and proliferation of cells. Anti-DOG1 antibody has been shown to be useful in the identification of gastrointestinal stromal tumors (GIST).

质量


IVD
IVD
IVD
RUO

联系

DOG1 Positive Control Slides, Product No. 244S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000420338
0000420338
0000405700
0000399595
0000400616

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J R Parfitt et al.
Histopathology, 52(7), 816-823 (2008-05-23)
Gastrointestinal Kaposi's sarcoma (KS) may mimic gastrointestinal stromal tumours (GISTs) histologically. Studies have shown that KS outside the gastrointestinal (GI) tract may express CD117, an antibody usually used to support a diagnosis of GIST. The aim was to evaluate the
Robert B West et al.
The American journal of pathology, 165(1), 107-113 (2004-06-25)
We recently characterized gene expression patterns in gastrointestinal stromal tumors (GISTs) using cDNA microarrays, and found that the gene FLJ10261 (DOG1, discovered on GIST-1), encoding a hypothetical protein, was specifically expressed in GISTs. The immunoreactivity of a rabbit antiserum to
Shigeharu Miwa et al.
Journal of gastroenterology, 43(7), 531-537 (2008-07-24)
Recently, the novel gene DOG1 has been found to be overexpressed in most gastrointestinal stromal tumors (GISTs) specifically within the field of soft tissue tumors. DOG1 might play a role in development of GISTs and have potential as a diagnostic
Inigo Espinosa et al.
The American journal of surgical pathology, 32(2), 210-218 (2008-01-29)
Gastrointestinal stromal tumors (GIST) occur primarily in the wall of the intestine and are characterized by activating mutations in the receptor tyrosine kinases genes KIT or PDGFRA. The diagnosis of GIST relies heavily on the demonstration of KIT/CD117 protein expression

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