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安全信息

23120

Sigma-Aldrich

α-氯醛糖

≥98.0% (chloralose, AT)

别名:

1,2-O-(2,2,2-三氯亚乙基)-α-D-呋喃(型)葡萄糖, Anhydro-D-glucochloral, 氯醛糖

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About This Item

经验公式（希尔记法）:
C8H11Cl3O6
CAS号:
15879-93-3
分子量:
309.53
Beilstein:
85418
EC 号:
240-016-7
MDL编号:
MFCD00005542
UNSPSC代码:
12352201
PubChem化学物质编号:
57648022
NACRES:
NA.21

质量水平

100

方案

≥98.0% (chloralose, AT)

表单

powder

旋光性

[α]20/D +17±2°, 5 hr, c = 2% in ethanol

杂质

15% Beta-chloralose

mp

178-184 °C

溶解性

water: soluble 1 gm in 225 ml at 15 °C
chloroform: slightly soluble
diethyl ether: soluble
glacial acetic acid: soluble
petroleum ether: insoluble

SMILES字符串

OC[C@@H](O)[C@H]1O[C@@H]2O[C@@H](O[C@@H]2[C@H]1O)C(Cl)(Cl)Cl

InChI

1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1

InChI key

OJYGBLRPYBAHRT-IPQSZEQASA-N

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相关类别

生化/生理作用

α-Chloralose stimulates the gama-aminobutyric acid (GABA)-induced chloride conductance of gama-aminobutyric acidA (GABAA) receptors expressed in Xenopus laevis oocytes.

组分

~85% α-氯醛糖与 ~15% β-氯醛糖的异构体混合物

其他说明

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

象形图

Skull and crossbonesEnvironment
GHS06,GHS09

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 3

靶器官

Central nervous system

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCK0932
BCCH8687
BCCF1953
BCCC7714
BCCC5785

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K M Garrett et al.
The Journal of pharmacology and experimental therapeutics, 285(2), 680-686 (1998-05-15)
alpha-Chloralose is widely used as an anesthetic in the laboratory due to its minimal effects on autonomic and cardiovascular systems, yet little is known about its mechanism of action. We examined the effects of alpha-chloralose on gamma-aminobutyric acid type A
R W Gear et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(16), 7175-7181 (1999-08-06)
We tested the hypothesis that noxious stimuli induce pain modulation by activation of supraspinal structures. We found that intense noxious stimuli (i.e., subdermal injection of capsaicin or paw immersion in hot water) induced profound attenuation of the jaw-opening reflex in
Karla Krautwald et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 32(2), 291-305 (2011-08-25)
To study how various anesthetics affect the relationship between stimulus frequency and generated functional magnetic resonance imaging (fMRI) signals in the rat dentate gyrus, the perforant pathway was electrically stimulated with repetitive low frequency (i.e., 0.625, 1.25, 2.5, 5, and
Kathleen A Williams et al.
Magnetic resonance imaging, 28(7), 995-1003 (2010-05-12)
Functional connectivity measures based upon low-frequency blood-oxygenation-level-dependent functional magnetic resonance imaging (BOLD fMRI) signal fluctuations have become a widely used tool for investigating spontaneous brain activity in humans. Still unknown, however, is the precise relationship between neural activity, the hemodynamic
E Gerace et al.
Journal of analytical toxicology, 36(6), 452-456 (2012-05-11)
Chloralose (alpha-chloralose) is a poisonous substance currently used as a rodenticide or avicide. It has primarily been used in Europe since 1893 as a human and veterinary hypnotic agent. Chloralose is a central nervous system depressant also acting as a
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