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生物来源
rabbit
质量水平
100
500
偶联物
unconjugated
抗体形式
Ig fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
表单
buffered aqueous solution
种属反应性
human
包装
vial of 0.1 mL concentrate (229A-14)
vial of 0.5 mL concentrate (229A-15)
bottle of 1.0 mL predilute (229A-17)
vial of 1.0 mL concentrate (229A-16)
bottle of 7.0 mL predilute (229A-18)
制造商/商品名称
Cell Marque®
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200-1:1000
控制
medullary carcinoma of thyroid
运输
wet ice
储存温度
2-8°C
可视化
cytoplasmic
一般描述
Calcitonin (thyrocalcitonin) is a 32 amino acid linear polypeptide hormone that is involved in regulating calcium metabolism. It is primarily produced by the parafollicular cells (also known as C cells) of the thyroid gland, though some neuroendocrine cells in other tissues, such as the respiratory and digestive tracts, can also synthesize calcitonin. Anti-calcitonin immunohistochemistry is an effective way for demonstrating the parafollicular C cells in the thyroid and the tumors arising from them, including C cell hyperplasia of the thyroid and medullary thyroid carcinoma, a neuroendocrine tumor that originates from C cells.
Immunohistochemical staining with anti-calcitonin antibodies has proven to be an effective way of demonstrating calcitonin-producing cells in the thyroid. C-cell hyperplasia and medullary thyroid carcinomas stain positive for calcitonin. Studies of calcitonin have resulted in the identification of a wide spectrum of C-cell proliferative abnormalities.
Immunohistochemical staining with anti-calcitonin antibodies has proven to be an effective way of demonstrating calcitonin-producing cells in the thyroid. C-cell hyperplasia and medullary thyroid carcinomas stain positive for calcitonin. Studies of calcitonin have resulted in the identification of a wide spectrum of C-cell proliferative abnormalities.
联系
Calcitonin Positive Control Slides, Product No. 229S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
制备说明
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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法规信息
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历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Y Dayal et al.
Cancer, 43(4), 1331-1338 (1979-04-01)
A nonfunctioning strumal carcinoid arising in a 49-year-old woman was studied by histochemical and immunocytochemical techniques. All tumor cells, irrespective of their architectural arrangement, showed properties of neuroendocrine-programmed cells, without any evidence of thyroid follicular cell differentiation. Foci of calcitonin-producing
Evidence for calcitonin--a new hormone from the parathyroid that lowers blood calcium.
D H COPP et al.
Endocrinology, 70, 638-649 (1962-05-01)
Plasma-immunoreactive-calcitonin in patients with non-thyroid tumours.
R C Coombes et al.
Lancet (London, England), 1(7866), 1080-1083 (1974-06-01)
Y Kameda et al.
Cell and tissue research, 206(3), 403-415 (1980-01-01)
The development of C-cell complexes was investigated in dog fetuses by an immunoperoxidase method with three specific antisera: anti-calcitonin, anti-C-thyroglobulin (C-Tg), and anti-19S thyroglobulin. Ultimobranchial bodies joined with the thyroid anlage and then dispersed into the parenchyma to form large
Calcitonin and carcinoembryonic antigen as tumor markers in medullary thyroid carcinoma.
R A DeLellis et al.
American journal of clinical pathology, 70(4), 587-594 (1978-10-01)
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