产品名称
神经酰胺 来源于牛脊髓, ≥98.0% (TLC)
biological source
bovine spinal cord
assay
≥98.0% (TLC)
form
solid
impurities
α-hydroxy fatty acids
solubility
chloroform/methanol (99:1): 20 mg/mL, clear, colorless
lipid type
sphingolipids
shipped in
wet ice
storage temp.
−20°C
Quality Level
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Application
神经酰胺用于研究其对程序性细胞死亡（细胞凋亡）以及胰岛素信号传导的影响。
Biochem/physiol Actions
神经酰胺是细胞膜的次要成分。激活非典型蛋白激酶 C（例如 PKCzeta）。
Other Notes
销售限制可能适用
Preparation Note
通过以下报道改进的实验方案从脑苷脂中提取：H.E.。Carter et al., J. Lipid Res. 2, 228 (1961)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β-secretase to generate a 99-aa C-terminal fragment (C99) that is then cleaved by γ-secretase to generate the β-amyloid (Aβ) found in senile plaques.
商品
Cellular oxidative stress is countered by enzymatic scavengers and antioxidant modulators against reactive oxygen species damage.
氧化应激，在一部分上，是由多种细胞过程产生的活性氧介导，并由诸如酶清除剂或抗氧化剂调节剂等细胞抗氧化剂机制所控制的。自由基，如活性氧，会通过细胞引起细胞损伤。
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