所有图片(1)

文件

21884

5（6）-Carboxy-2′，7′-二氯荧光素二乙酸酯

Name: 5（6）-Carboxy-2′，7′-二氯荧光素二乙酸酯
Brand: SIGMA

BioReagent, suitable for fluorescence, ≥85% (HPCE)

别名:

5&6DH-DA, CDFDA, 羧基-DCFDA

登录查看公司和协议定价

所有图片(1)

About This Item

经验公式（希尔记法）:

C₂₅H₁₄Cl₂O₉

CAS号:

127770-45-0

分子量:

529.28

Beilstein:

7505106

MDL编号:

MFCD08459585

UNSPSC代码:

12352106

PubChem化学物质编号:

57647949

NACRES:

NA.32

产品线

BioReagent

质量水平

100

检测方案

≥85% (HPCE)

mp

210 °C (dec.) (lit.)

溶解性

DMF: soluble
DMSO: soluble
methanol: soluble

荧光

λ_ex 470 nm; λ_em 529 nm in 0.1 M Tris pH 8.0 (esterase)

适用性

suitable for fluorescence

储存温度

−20°C

SMILES字符串

CC(=O)Oc1cc2Oc3cc(OC(C)=O)c(Cl)cc3C4(OC(=O)c5cc(ccc45)C(O)=O)c2cc1Cl.CC(=O)Oc6cc7Oc8cc(OC(C)=O)c(Cl)cc8C9(OC(=O)c%10ccc(cc9%10)C(O)=O)c7cc6Cl

InChI

1S/2C25H14Cl2O9/c1-10(28)33-21-8-19-15(6-17(21)26)25(14-4-3-12(23(30)31)5-13(14)24(32)36-25)16-7-18(27)22(34-11(2)29)9-20(16)35-19;1-10(28)33-21-8-19-15(6-17(21)26)25(14-5-12(23(30)31)3-4-13(14)24(32)36-25)16-7-18(27)22(34-11(2)29)9-20(16)35-19/h2*3-9H,1-2H3,(H,30,31)

InChI key

LZMPJBOMBCYYMP-UHFFFAOYSA-N

一般描述

5（6）-羧基-2′,7′-二氯荧光素二乙酸酯或 CDFDA 是一种荧光氧化剂传感探针。它是一种细胞内探针，作为前底物添加到细胞中，在酯酶水解后产生称为 CDF 的荧光产物。

应用

使用 5（6）-羧基-2′,7′-二氯荧光素二乙酸酯或羧基-DCFDA 作为细胞渗透探针来检测细胞内活性氧（ROS）。阴离子荧光染料 5（6）-羧基-2′,7′-二氯荧光素二乙酸酯适合于通过靶细胞研究多药耐药性（MDR）。

包装

无底玻璃瓶。内含物装在插入的融合锥内。

分析说明

Exc_max：504 nm（Lit.）

其他说明

对荧光对细胞内 pH 敏感性低的细胞内酯酶底物

象形图

GHS07

警示用语：

Warning

危险声明

H315,H319,H335

预防措施声明

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

输入产品批号来搜索分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Molecular analysis of the yeast VPS3 gene and the role of its product in vacuolar protein sorting and vacuolar segregation during the cell cycle.

C K Raymond et al.

The Journal of cell biology, 111(3), 877-892 (1990-09-01)

vps3 mutants of the yeast Saccharomyces cerevisiae are impaired in the sorting of newly synthesized soluble vacuolar proteins and in the acidification of the vacuole (Rothman, J. H., and T. H. Stevens. Cell. 47:1041-1051; Rothman, J. H., C. T. Yamashiro

Inhibition of multidrug resistance-associated protein 2 (MRP2) activity by the contraceptive nomegestrol acetate in HepG2 and Caco-2 cells.

Guillermo Nicolás Tocchetti et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 122, 205-213 (2018-07-10)

Multidrug resistance-associated protein 2 (MRP2) plays a key role in hepatic and intestinal disposition of endo- and xenobiotics. Several therapeutic agents modulate MRP2 activity resulting in pharmacological interactions. Nomegestrol acetate (NMGA) is a progestogen increasingly used in contraceptive formulations. The

Rhinacanthin-C enhances doxorubicin cytotoxicity via inhibiting the functions of P-glycoprotein and MRP2 in breast cancer cells.

Tassarut Chaisit et al.

European journal of pharmacology, 795, 50-57 (2016-12-06)

Rhinacanthin-C is a major bioactive naphthoquinone ester found in Rhinacanthus nasutus Kurz (Acanthaceae). This compound has potential therapeutic value as an anticancer and antiviral agent. In this study, we investigated an enhancement effect of rhinacanthin-C on doxorubicin cytotoxicity in human

Surgical treatment of the symptomatic juvenile flexible flatfoot condition.

G L Dockery

Clinics in podiatric medicine and surgery, 4(1), 99-117 (1987-01-01)

(-)-Epigallocatechin-3-gallate alleviates doxorubicin-induced cardiotoxicity in sarcoma 180 tumor-bearing mice.

Yu-Fei Yao et al.

Life sciences, 180, 151-159 (2016-12-14)

(-)-Epigallocatechin-3-gallate (EGCG), a major green tea polyphenol compound, plays an important role in the prevention of cardiovascular disease and cancer. The present study aimed to investigate the effects of EGCG on doxorubicin (DOX)-induced cardiotoxicity in Sarcoma 180 (S180) tumor-bearing mice.

查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门

文件