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Merck
CN

21884

5（6）-Carboxy-2′，7′-二氯荧光素二乙酸酯

BioReagent, suitable for fluorescence, ≥85% (HPCE)

别名:

5&6DH-DA, CDFDA, 羧基-DCFDA

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关于此项目

经验公式（希尔记法）:
C25H14Cl2O9
化学文摘社编号:
127770-45-0
分子量:
529.28
UNSPSC Code:
12352106
NACRES:
NA.32
PubChem Substance ID:
57647949
MDL number:
MFCD08459585
Beilstein/REAXYS Number:
7505106

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产品名称

5（6）-Carboxy-2′，7′-二氯荧光素二乙酸酯, BioReagent, suitable for fluorescence, ≥85% (HPCE)

InChI

1S/2C25H14Cl2O9/c1-10(28)33-21-8-19-15(6-17(21)26)25(14-4-3-12(23(30)31)5-13(14)24(32)36-25)16-7-18(27)22(34-11(2)29)9-20(16)35-19;1-10(28)33-21-8-19-15(6-17(21)26)25(14-5-12(23(30)31)3-4-13(14)24(32)36-25)16-7-18(27)22(34-11(2)29)9-20(16)35-19/h2*3-9H,1-2H3,(H,30,31)

SMILES string

CC(=O)Oc1cc2Oc3cc(OC(C)=O)c(Cl)cc3C4(OC(=O)c5cc(ccc45)C(O)=O)c2cc1Cl.CC(=O)Oc6cc7Oc8cc(OC(C)=O)c(Cl)cc8C9(OC(=O)c%10ccc(cc9%10)C(O)=O)c7cc6Cl

InChI key

LZMPJBOMBCYYMP-UHFFFAOYSA-N

product line

BioReagent

assay

≥85% (HPCE)

mp

210 °C (dec.) (lit.)

solubility

DMF: soluble
DMSO: soluble
methanol: soluble

fluorescence

λex 470 nm; λem 529 nm in 0.1 M Tris pH 8.0 (esterase)

suitability

suitable for fluorescence

storage temp.

−20°C

Quality Level

100

相关类别

Analysis Note

Excmax：504 nm（Lit.）

Application

使用 5（6）-羧基-2′,7′-二氯荧光素二乙酸酯或羧基-DCFDA 作为细胞渗透探针来检测细胞内活性氧（ROS）。 阴离子荧光染料 5（6）-羧基-2′,7′-二氯荧光素二乙酸酯适合于通过靶细胞研究多药耐药性（MDR）。

General description

5（6）-羧基-2′,7′-二氯荧光素二乙酸酯或 CDFDA 是一种荧光氧化剂传感探针。 它是一种细胞内探针，作为前底物添加到细胞中，在酯酶水解后产生称为 CDF 的荧光产物。

Other Notes

对荧光对细胞内 pH 敏感性低的细胞内酯酶底物

Packaging

无底玻璃瓶。内含物装在插入的融合锥内。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCP1669
BCCN0946
BCCL2091
BCCK0844
BCCG3329

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