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Merck
CN
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文件

213942

Sigma-Aldrich

3-甲基胆蒽

98%

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别名:
20-Methylcholanthrene, Methylcholanthrene
经验公式（希尔记法）:
C21H16
CAS号:
56-49-5
分子量:
268.35
Beilstein:
1913890
EC 号:
200-276-4
MDL编号:
MFCD00003704
UNSPSC代码:
12352005
PubChem化学物质编号:
57647926
NACRES:
NA.25

质量水平

200

检测方案

98%

形式

solid

bp

280 °C/80 mmHg (lit.)

mp

178-180 °C (lit.)

SMILES字符串

Cc1ccc2cc3c(ccc4ccccc34)c5CCc1c25

InChI

1S/C21H16/c1-13-6-7-15-12-20-17-5-3-2-4-14(17)8-9-18(20)19-11-10-16(13)21(15)19/h2-9,12H,10-11H2,1H3

InChI key

PPQNQXQZIWHJRB-UHFFFAOYSA-N

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应用

3-甲基胆蒽用于通过 Bhas 42细胞转化测定评估其肿瘤引发活性。也用来诱导细胞色素 P450 的活性。

生化/生理作用

3-甲基胆蒽是致癌物质，用于诱导培养细胞转化。也可用于诱发实验动物发生纤维肉瘤和皮肤癌。3-甲基胆蒽是芳香烃受体的强效激动剂。

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H350,H413

预防措施声明

P201 - P273 - P308 + P313

危险分类

Aquatic Chronic 4 - Carc. 1B

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Nadine Y Crowe et al.
The Journal of experimental medicine, 196(1), 119-127 (2002-07-03)
Natural killer (NK) T cells initiate potent antitumor responses when stimulated by exogenous factors such as interleukin (IL)-12 or alpha-galactosylceramide (alpha-GalCer), however, it is not clear whether this reflects a physiological role for these cells in tumor immunity. Through adoptive
A high-throughput Bhas 42 cell transformation assay for the determination of the carcinogenicity of three herbal extracts
Pu J, et al.
Fundamental Toxicological Sciences, 3(4), 157-166 (2016)
Aryl Hydrocarbon Receptor: A New Player of Pathogenesis and Therapy in Cardiovascular Diseases
Yi T, et al.
BioMed Research International, 1-11 (2018)
Simple machine perfusion significantly enhances hepatocyte yields of ischemic and fresh rat livers
Izamis ML, et al.
Cell medicine, 4(3), 109-123 (2013)
Elin Swedenborg et al.
Molecular and cellular endocrinology, 362(1-2), 39-47 (2012-05-29)
The two estrogen receptor isoforms ERα and ERβ mediate biological effects of estrogens, but are also targets for endocrine disruptive chemicals (EDCs), compounds that interfere with hormonal signaling. 3-Methylcholanthrene (3-MC) and dioxin (TCDD) are EDCs and prototypical aryl hydrocarbon receptor
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