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Merck
CN

21279

Calyculin A

from Discodermia calyx, ≥90% (HPLC), protein phosphatases types 1 and 2A inhibitor, solid

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关于此项目

经验公式（希尔记法）:
C50H81N4O15P
化学文摘社编号:
101932-71-2
分子量:
1009.17
UNSPSC Code:
12352200
PubChem Substance ID:
329752128
NACRES:
NA.77
Beilstein/REAXYS Number:
4903216
MDL number:
MFCD06795864

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产品名称

花萼海绵诱癌素A 来源于花萼国皮海绵, ≥90% (HPLC)

SMILES string

COC[C@@H]([C@H](O)[C@H](O)C(=O)NCC[C@H](C)c1nc(\C=C\C[C@@H]2O[C@]3(C[C@@H](O)[C@@H]2C)OC([C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C(C)\C(C)=C\C=C\C(C)=C/C#N)OC)[C@H](OP(O)(O)=O)C3(C)C)co1)N(C)C

InChI

1S/C50H81N4O15P/c1-29(20-22-51)16-14-17-30(2)32(4)24-33(5)42(57)35(7)38(55)25-41(65-13)45-46(69-70(61,62)63)49(8,9)50(68-45)26-39(56)34(6)40(67-50)19-15-18-36-27-66-48(53-36)31(3)21-23-52-47(60)44(59)43(58)37(28-64-12)54(10)11/h14-18,20,24,27,31,33-35,37-46,55-59H,19,21,23,25-26,28H2,1-13H3,(H,52,60)(H2,61,62,63)/b16-14+,18-15+,29-20-,30-17+,32-24+/t31-,33+,34-,35-,37-,38-,39+,40-,41-,42+,43-,44-,45+,46-,50+/m0/s1

InChI key

FKAWLXNLHHIHLA-YCBIHMBMSA-N

assay

≥90% (HPLC)

form

solid

storage temp.

−20°C

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相关类别

Biochem/physiol Actions

1型和2A型蛋白磷酸酶抑制剂；海洋毒素，强效肿瘤促进剂。

Other Notes

蛋白磷酸酶1和2A的有效抑制剂。 Pp1的功效是冈田酸的十倍以上

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

高风险级别生物产品--毒素类产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN8496
BCCN8497
BCCN8498
BCCN0921
BCCM5531

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Michael A Kuefner et al.
International journal of radiation biology, 89(6), 424-432 (2013-02-01)
The purpose of this study was to investigate the effect of calyculin A on the number of γ-H2AX foci (phosphorylated histone variant 2AX) in lymphocytes after in vitro and in vivo irradiation with rather low doses as they are used
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