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17938

Sigma-Aldrich

25-羟基维生素D3 一水合物

≥99.0% (HPLC)

别名:

25-羟基胆钙化醇

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选择尺寸

25 MG
CN¥1,319.86
200 MG
CN¥3,601.49
500 MG
CN¥6,917.80
1 G
CN¥11,568.31

CN¥1,319.86

国内现货，预计发货时间April 24, 2025详情

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25 MG
CN¥1,319.86
200 MG
CN¥3,601.49
500 MG
CN¥6,917.80
1 G
CN¥11,568.31

About This Item

经验公式（希尔记法）:
C27H44O2 · H2O
CAS号:
63283-36-3
分子量:
418.65
Beilstein:
4270041
MDL编号:
MFCD00867077
UNSPSC代码:
12352205
eCl@ss:
34058003
PubChem化学物质编号:
57647690
NACRES:
NA.79

CN¥1,319.86

国内现货，预计发货时间April 24, 2025详情

获取大包装报价

生物来源

synthetic

质量水平

200

方案

≥99.0% (HPLC)

表单

powder or crystals

颜色

white to off-white

运输

dry ice

储存温度

−20°C

SMILES字符串

[H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C)[C@H](C)CCCC(C)(C)O

InChI

1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1

InChI key

JWUBBDSIWDLEOM-DTOXIADCSA-N

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此商品
700002P700054P700061P
DC-胆固醇HCl Avanti Research™ - A Croda Brand 700001P, powder

700001P

DC-胆固醇HCl

F7-Cholesterol Avanti Research™ - A Croda Brand

700002P

F7-Cholesterol

5α,6β-dihydroxycholestanol Avanti Research™ - A Croda Brand

700054P

5α,6β-dihydroxycholestanol

24(S)-羟基胆固醇 Avanti Research™ - A Croda Brand

700061P

24(S)-羟基胆固醇

packaging

pkg of 1 × 1 g (700001P-1g), pkg of 1 × 25 mg (700001P-25mg), pkg of 1 × 200 mg (700001P-200mg), pkg of 1 × 500 mg (700001P-500mg)

packaging

pkg of 1 × 5 mg (700002P-5mg)

packaging

pkg of 1 × 25 mg (700054P-25mg), pkg of 1 × 5 mg (700054P-5mg)

packaging

pkg of 1 × 1 mg (700061P-1mg), pkg of 1 × 5 mg (700061P-5mg)

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

form

powder

form

powder

form

powder

form

powder

manufacturer/tradename

Avanti Polar Lipids 700001P

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

生化/生理作用

胆钙化醇是维生素D3的一种失活形式，它在经历各种水平的羟基化后可形成活性的维生素D3类似物。 1α-羟基维生素D3（α-骨化醇）是一种合成类似物，其可代谢为1,25-二羟胆钙化醇（维生素D3的生物活性形式）。胆钙化醇的其他类似物可由不同的羟基化产生。 25-二羟胆钙化醇是维生素D3的主要循环形式，是1α，25-二羟胆钙化醇的生理前体。该转化由25-羟基维生素D3 1-α-羟化酶（VD3 1A羟化酶）——也称为细胞色素p450 27B1 (CYP27B1)——进行催化。

包装

无底玻璃瓶。内容物包含在插入的融合锥内。

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产品编号
说明
价格

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    WXBF4381V
    WXBF3633V
    BCCH8092
    BCCF9309
    BCCF2261

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    H F DeLuca
    Biochemical Society transactions, 10(3), 147-158 (1982-06-01)
    Cholecalciferol must be regarded as a pro-hormone rather than a vitamin, since it is normally produced in skin under the influence of ultraviolet light. Cholecalciferol must be metabolized in liver to 25-hydroxycholecalciferol and subsequently to 1,25-dihydroxycholecalciferol before it can act
    Matthew J Rowling et al.
    The Journal of nutrition, 136(11), 2754-2759 (2006-10-24)
    The major circulating form of vitamin D is 25-hydroxycholecalciferol [25(OH)D3], which is delivered to target tissues in complex with the serum vitamin D binding protein (DBP). We recently observed that mammary cells can metabolize 25(OH)D3 to 1,25-dihydroxycholecalciferol [1,25(OH)(2)D3], the vitamin
    Carly M Kemmis et al.
    The Journal of nutrition, 136(4), 887-892 (2006-03-22)
    1alpha,25-dihydroxycholecalciferol [1alpha,25(OH)2D3], the active form of cholecalciferol, is a negative growth regulator of breast cancer cells. CYP27B1 is a cytochrome P450-containing hydroxylase expressed in kidney and other tissues that generates 1alpha,25(OH)2D3 from an inactive vitamin D precursor 25-hydroxycholecalciferol [25(OH)D3]. In
    Fadia S AlBuhairan et al.
    The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 57(3), 263-269 (2015-08-25)
    With the increasing burden of noncommunicable disease, adolescence is viewed as an opportune time to prevent the onset of certain behaviors and promote healthy states. Although adolescents comprise a considerable portion of Saudi Arabia's population, they have received insufficient attention
    Peter Daley et al.
    The Lancet. Infectious diseases, 15(5), 528-534 (2015-04-13)
    Vitamin D has immunomodulatory effects that might aid clearance of mycobacterial infection. We aimed to assess whether vitamin D supplementation would reduce time to sputum culture conversion in patients with active tuberculosis. We did this randomised, double-blind, placebo-controlled, superiority trial
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