推荐产品
方案
≥95.0% (HPLC)
应用
metabolomics
vitamins, nutraceuticals, and natural products
SMILES字符串
COc1cc(ccc1O)C2=C(O)C(=O)c3c(O)cc(O)cc3O2
InChI
1S/C16H12O7/c1-22-11-4-7(2-3-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3
InChI key
IZQSVPBOUDKVDZ-UHFFFAOYSA-N
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应用
生化/生理作用
异鼠李素具有抗氧化、抗炎症、抗肿瘤、抗菌和抗病毒的作用。[6]作为一种潜在的神经保护剂，可抑制糖尿病（DM）患者海马结构的神经退行性变。[1]低水平的异鼠李素可以作为一种抗糖尿病药物，促进骨骼肌细胞对葡萄糖的摄取并在高血糖情况下维持血糖稳态。[2]它调节了核因子 kB（NF-κB）、磷脂酰肌醇 3-激酶（PI3K）/蛋白激酶（AKT）、丝裂原活化蛋白激酶（MAPK）等细胞信号通路。[6]异鼠李素对动脉粥样硬化和心血管疾病具有保护和治疗作用。[6]
异鼠李素通过干扰脂肪干细胞的分化来抑制脂肪形成，其机制为稳定 β-连环蛋白和上调 Wnt 信号通路。
包装
无底玻璃瓶。内含物在插入的融合锥体内。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Gang Gong et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 128, 110301-110301 (2020-06-06)
Isorhamnetin is one of the most important active ingredients in the fruits of Hippophae rhamnoides L. and the leaves of Ginkgo biloba L., which possesses extensive pharmacological activities. At present, there have been numerous investigations on isorhamnetin, which has the
Lutz Franke et al.
Journal of medicinal chemistry, 50(11), 2640-2646 (2007-04-28)
A natural product collection and natural-product-derived combinatorial libraries were virtually screened for potential inhibitors of human 5-lipoxygenase (5-LO) activity. We followed a sequential ligand-based approach in two steps. First, similarity searching with a topological pharmacophore descriptor (CATS 2D method) was
Nida Jamali-Raeufy et al.
Journal of chemical neuroanatomy, 102, 101709-101709 (2019-11-08)
Isorhamnetin, a derivative of quercetin, exerts antioxidant and anti-inflammatory effects in different diseases, and we examined its protective effects against diabetes-related changes in the brain. A single dose of a freshly prepared solution of streptozotocin (STZ) (60 mg/kg body weight) was
Quercetin and its metabolite isorhamnetin promote glucose uptake through different signalling pathways in myotubes
Jiang H, et al.,
Scientific Reports, 1-15 (2019)
Juraj Majtan et al.
Archives of dermatological research, 305(7), 619-627 (2013-07-03)
Matrix metalloproteinase-9 (MMP-9) appears to be a major protease responsible for the degradation of matrix and growth-promoting agents in chronic wounds. Honey has been successfully used for treating non-healing wounds associated with infections. However, the mechanisms of its action at
商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。
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