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Merck
CN

14370

Sigma-Aldrich

胆红素

purum, ≥95.0% (UV)

别名:

Bile pigment, Hemetoidin

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About This Item

经验公式(希尔记法):
C33H36N4O6
CAS号:
分子量:
584.66
Beilstein:
74376
EC 号:
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.25

等级

purum

质量水平

检测方案

≥95.0% (UV)

形式

powder

灼烧残渣

≤0.5%

SMILES字符串

CC1=C(C=C)\C(NC1=O)=C\c2[nH]c(Cc3[nH]c(\C=C4/NC(=O)C(C=C)=C4C)c(C)c3CCC(O)=O)c(CCC(O)=O)c2C

InChI

1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-

InChI key

BPYKTIZUTYGOLE-IFADSCNNSA-N

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一般描述

胆红素是血红素分解代谢的最终产物,通过酶胆绿素还原酶的作用还原代谢前体胆绿素而产生。

应用

使用胆红素作为肌红蛋白、肌酸激酶-MB(CK-MB)和肌钙蛋白-I 体外干扰和稳定性测试的干扰物质。此外,还被用作干扰剂,以测试肝素红试剂盒检测各种肝素的有效性。

生化/生理作用

胆红素是一种活性氧化 DNA 裂解剂,也是一种有效的抗氧化剂,即羟基猝灭剂。这种胆色素同时具有抗氧化性和毒害性。它是血管平滑肌细胞增殖(VSMC)的天然抑制剂。当用于肺/血管疾病的治疗药物时,它显示出抗炎和抗增殖特性。血清胆红素浓度略高于正常水平表示心脏疾病发病率较低。它是心脏移植和 T 细胞介导免疫功能紊乱的治疗药物。
超过99%的胆红素与白蛋白结合运输。胆红素水平异常高会导致严重的神经损伤,但轻度升高与抗氧化应激反应有关。

分析说明

λmax。∼453 nm,摩尔吸光度>56100(溶剂为氯仿)

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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