生物来源
rabbit
质量水平
100
500
偶联物
unconjugated
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
EP201, monoclonal
描述
(For In Vitro Diagnostic Use in Select Regions (See Chart))
形式
buffered aqueous solution
种属反应性
human
包装
bottle of 1.0 mL predilute (138R-27)
bottle of 7.0 mL predilute (138R-28)
vial of 0.1 mL concentrate (138R-24)
vial of 0.5 mL concentrate (138R-25)
vial of 1.0 mL concentrate (138R-26)
制造商/商品名称
Cell Marque™
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
同位素/亚型
IgG
运输
wet ice
储存温度
2-8°C
基因信息
human ... SDC1(6382)
一般描述
CD138, Syndecan 1, is expressed in the late stages of B-cell differentiation with progression towards plasma cells.1,2 It can be used to differentiate lymphoplasmacytic lymphoma from marginal zone lymphoma.1 ALK+ large B-cell lyphoma (LBCL) usually strongly expresses CD138 whereas lineage-associated markers such as anti-CD20 and anti-CD79a do not stain ALK+LBCL.3,7 Anti-CD138 is immunoreactive with HHV8-associated primary effusion lymphoma even though the lymphoma cells lack the expression of B-cell markers.5 Anti-CD138 is a good marker to identify and enumerate plasma cells, benign, reactive, or malignant, in bone marrow biopsy specimens.4,6 CD138 is also expressed in epithelial cells.6
质量
 IVD |  IVD |  IVD |  RUO |
联系
CD138 Positive Control Slides, Product No. 138S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
制备说明
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview.
E Sabattini et al.
Pathologica, 102(3), 83-87 (2010-12-22)
Fionnuala P O'Connell et al.
American journal of clinical pathology, 121(2), 254-263 (2004-02-27)
We evaluated the immunohistochemical profile and specificity of CD138 reactivity in 238 specimens from hematopoietic and nonhematopoietic neoplasms. In 91 bone marrow biopsies, CD138 reactivity was observed for nonneoplastic plasma cells, neoplastic plasma cells in multiple myeloma cases (43/43), and
M Chilosi et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 12(12), 1101-1106 (2000-01-05)
Detection of abnormal numbers and/or distribution of bone marrow (BM) plasma cells (PCs) on trephine biopsies can be important in the differential diagnosis of multiple myeloma (MM) and other PC disorders. A variety of immunohistochemical markers can potentially improve the
A Sebestyén et al.
British journal of haematology, 104(2), 412-419 (1999-03-02)
Syndecan-1, an important transmembrane heparan sulphate proteoglycan is expressed in distinct stages of differentiation of normal lymphoid cells: in pre-B cells and Ig-producing plasma cells; however, its normal function, or presence in lymphoid malignancies, is still largely unknown. The expression
Lluís Colomo et al.
The American journal of surgical pathology, 28(6), 736-747 (2004-05-29)
Plasmablastic lymphoma was initially described as a variant of diffuse large B-cell lymphoma (DLBCL) involving the oral cavity of HIV+ patients and characterized by immunoblastic morphology and a plasma cell phenotype. However, other lymphomas may exhibit similar morphologic and immunophenotypic
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