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安全信息

135R-1

Sigma-Aldrich

CD35 (EP197) Rabbit Monoclonal Primary Antibody

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别名:
C3-binding protein, C3BR, C3b/C4b receptor, C4BR, CD35 antigen, CR1, Complement Receptor 1, Complement component (3b/4b) receptor 1 (Knops blood group), Knops blood group antigen
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP197, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

形式

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (135R-14)
vial of 0.1 mL concentrate Research Use Only (135R-14-RUO)
vial of 0.5 mL concentrate (135R-15)
vial of 1.0 mL concentrate (135R-16)
vial of 1.0 mL concentrate Research Use Only (135R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (135R-17-RUO)
vial of 1.0 mL predilute ready-to-use (135R-17)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (135R-18-RUO)
vial of 7.0 mL predilute ready-to-use (135R-18)

制造商/商品名称

Cell Marque™

浓度

0.1-5.0 μg/mL (predilute)
2.5-125 μg/mL (concentrate)

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同位素/亚型

IgG

控制

tonsil

运输

wet ice

储存温度

2-8°C

可视化

membranous

基因信息

human ... CR1(1378)

相关类别

一般描述

CD35 (complement receptor 1) is a cell membrane-bound, monomeric glycoprotein found on numerous cell types including erythrocytes, leukocytes, glomerular podocytes, and follicular dendritic cells. The primary function of CD35 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. CD35 antigen is found on erythrocytes, B cells, a subset of T cells, monocytes, as well as eosinophils and neutrophils. Anti-CD35 is considered a mature B-cell marker which labels follicular dendritic reticulum cells and tumors derived from such cells such as follicular dendritic cell tumor/sarcoma.

质量

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

联系

CD35 Positive Control Slides, Product No. 135S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

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Germinal centre-like versus undifferentiated stromal immunophenotypes in follicular lymphoma.
Chang KC, Huang X, Medeiros LJ, et al.
The Journal of Pathology, 201(3), 404-412 (2003)
Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases.
Pileri SA, Grogan TM, Harris NL, et al.
Histopathology, 41(1), 1-29 (2002)
Immunohistochemical recognition of human follicular dendritic cell (FDCs) in routinely processed paraffin section.
Kunihikom, M., et al.
The Journal of Histochemistry and Cytochemistry, 50, 1475-1486 (2002)
Extranodal follicular dendritic cell sarcoma of the head and neck region: three new cases, with a review of the literature.
Biddle DA, Ro JY, Yoon GS, et al.
Modern Pathology, 15(1), 50-58 (2002)
Mediastinal mixed dendritic cell sarcoma with hybrid features.
Dillon KM, Hill CM, Cameron CH, et al.
Journal of Clinical Pathology, 55(10), 791-794 (2002)
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