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质量水平
检测方案
≥98.0% (HPLC)
形式
solid
SMILES字符串
O.O=C1NC(=O)c2[nH]nnc2N1
InChI
1S/C4H3N5O2.H2O/c10-3-1-2(8-9-7-1)5-4(11)6-3;/h(H3,5,6,7,8,9,10,11);1H2
InChI key
VKEGPGRANAWNIN-UHFFFAOYSA-N
应用
8-Azaxanthine monohydrate has been used to determine the crystal and molecular structure of 1,3-dimethyl-8-azaxanthine (HDAX) monohydrate by X-ray diffraction.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Paxton Forgue et al.
Journal of proteome research, 5(8), 1916-1923 (2006-08-08)
We describe a general protocol for using comparative NMR metabolomics data to infer in vivo efficacy, specificity and toxicity of chemical leads within a drug discovery program. The methodology is demonstrated using Aspergillus nidulans to monitor the activity of urate
Pascal Retailleau et al.
Acta crystallographica. Section D, Biological crystallography, 60(Pt 3), 453-462 (2004-03-03)
High-resolution X-ray structures of the complexes of Aspergillus flavus urate oxidase (Uox) with three inhibitors, 8-azaxanthin (AZA), 9-methyl uric acid (MUA) and oxonic acid (OXC), were determined in an orthorhombic space group (I222). In addition, the ligand-free enzyme was also
Monika Budayova-Spano et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 62(Pt 3), 306-309 (2006-03-03)
Crystallization and preliminary neutron diffraction measurements of rasburicase, a recombinant urate oxidase enzyme expressed by a genetically modified Saccharomyces cerevisiae strain, complexed with a purine-type inhibitor (8-azaxanthin) are reported. Neutron Laue diffraction data were collected to 2.1 A resolution using
Nathalie Colloc'h et al.
Biochimica et biophysica acta, 1764(3), 391-397 (2006-02-16)
We report the three-dimensional structure determined by high-pressure macromolecular crystallography (HPMX) of a 135-kDa homo-tetrameric enzyme, urate oxidase from Aspergillus flavus complexed with its potent inhibitor 8-azaxanthin. Urate oxidase crystals are quite sensitive to pressure, as three-dimensional order is lost
Laurent Fraisse et al.
Analytical biochemistry, 309(2), 173-179 (2002-11-05)
Urate oxidase (E.C.1.7.3.3; uricase, urate oxygen oxidoreductase) is an enzyme of the purine breakdown pathway that catalyzes the oxidation of uric acid in the presence of oxygen to allantoin and hydrogen peroxide. A 96-well plate assay measurement of urate oxidase
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