推荐产品
应用
3-羟基异丁酸（HIBA）可用于研究参与支链氨基酸代谢的酶的分布、表征和动力学，例如，3-羟基异丁酸脱氢酶（EC：1.1.1.31）和3-羟基异丁酰辅酶A水解酶（EC：3.1.2.4）。（R）-β-羟基异丁酸酯可用于立体特异性研究。
生化/生理作用
尿中3-羟基异丁酸浓度升高是代谢性疾病3-羟基异丁酸尿症的生化标志。
包装
无底玻璃瓶。内含物装在插入的融合锥内。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Neuropathology of 3-hydroxyisobutyric aciduria, an autopsy case report.
Xianyuan Song et al.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 36(4), 483-486 (2009-08-05)
Jörn Oliver Sass et al.
Journal of inherited metabolic disease, 35(3), 437-442 (2011-08-25)
3-hydroxyisobutyric aciduria is an organic aciduria with a poorly understood biochemical basis. It has previously been assumed that deficiency of 3-hydroxyisobutyrate dehydrogenase (HIBADH) in the valine catabolic pathway is the underlying enzyme defect, but more recent evidence makes it likely
Ference J Loupatty et al.
American journal of human genetics, 80(1), 195-199 (2006-12-13)
Only a single patient with 3-hydroxyisobutyryl-CoA hydrolase deficiency has been described in the literature, and the molecular basis of this inborn error of valine catabolism has remained unknown until now. Here, we present a second patient with 3-hydroxyisobutyryl-CoA hydrolase deficiency
Radovan Murín et al.
Journal of neurochemistry, 105(4), 1176-1186 (2008-02-21)
The branched-chain amino acids (BCAAs)--isoleucine, leucine, and valine--belong to the limited group of substances transported through the blood-brain barrier. One of the functions they are thought to have in brain is to serve as substrates for meeting parenchymal energy demands.
Ronald J A Wanders et al.
Journal of inherited metabolic disease, 35(1), 5-12 (2010-11-26)
Valine is one of the three branched-chain amino acids which undergoes oxidation within mitochondria. In this paper, we describe the current state of knowledge with respect to the enzymology of the valine oxidation pathway and the different disorders affecting oxidation.
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