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250 MG
¥1,494.55
1 G
¥4,999.23
About This Item
线性分子式:
CH3(CH2)4(CH=CHCH2)4CH2CH2CO2H
CAS号:
分子量:
304.47
Beilstein:
1713889
EC 号:
MDL编号:
UNSPSC代码:
12352211
PubChem化学物质编号:
NACRES:
NA.25
推荐产品
生物来源
fungus
质量水平
方案
>95.0% (GC)
表单
liquid
折射率
n20/D 1.4872 (lit.)
沸点
169-171 °C/0.15 mmHg (lit.)
mp
−49 °C (lit.)
密度
0.922 g/mL at 25 °C (lit.)
官能团
carboxylic acid
脂质类型
omega FAs
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此商品 | A3611 | 735000 | A8798 |
|---|---|---|---|
| assay >95.0% (GC) | assay ≥98.5% (GC) | assay ≥98% (CP) | assay ≥99% (capillary GC) |
| biological source fungus | biological source non-animal source | biological source - | biological source Porcine liver |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| form liquid | form liquid | form liquid | form waxy solid |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
应用
生化/生理作用
花生四烯酸 (AA) 是一种 ω6 不饱和脂肪酸，是细胞膜磷脂的组分。在炎症反应中，水解磷脂酶 A2 可将 AA 从膜磷脂中释放出来。然后，AA 可被至少两种环加氧酶 (COX) 亚型代谢为前列腺素和血栓烷，被脂氧合酶代谢为白三烯和脂氧素，以及通过细胞色素 p450 催化代谢为环氧-二十碳三烯酸。AA 及其代谢产物在多种生物过程中发挥着重要作用，包括信号转导、平滑肌收缩、趋化性、细胞增殖和分化，以及细胞凋亡。已证实 AA 可与 G 蛋白的亚基结合，抑制 Ras GTP 酶激活蛋白 (GAP) 的活性。AA 的细胞摄取需要消耗能量并涉及跨细胞质膜的蛋白质辅助运输。
花生四烯酸及其代谢产物在多种生物过程中发挥着重要作用，包括信号转导、平滑肌收缩、趋化性、细胞增殖和分化，以及细胞凋亡。
花生四烯酸可刺激MDA-MB-435人转移癌细胞与细胞外基质分子（胶原蛋白IV和玻连蛋白）的粘附 。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
235.4 °F - closed cup
闪点(°C)
113 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)
Lipid sensing by mTOR via de novo synthesis of phosphatidic acid
Menon D, et al.
The Journal of Biological Chemistry, jbc-M116 (2017)
Lipid components of bile increase the protective effect of conjugated bile salts against antifungal drugs
Hsieh SH and Brock M
Fungal Biology, 121(11), 929-938 (2017)
Shih-Hung Hsieh et al.
Fungal biology, 121(11), 929-938 (2017-10-17)
Fungi and bacteria can persist in the human gall bladder. Previous studies have shown that bile protects Candida albicans in this cryptic host niche from antifungals, providing a reservoir for intestinal re-colonization after discontinuation of antifungal therapy. Bile and conjugated
Angiogenesis-a crucial step in breast cancer growth, progression and dissemination by Raman imaging
Kopec M and Abramczyk H
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 198, 338-345 (2018)
Yanhong Hao et al.
iScience, 24(9), 102974-102974 (2021-08-17)
Asymptomatic infection is a big challenge in curbing the spread of COVID-19. However, its identification and pathogenesis elucidation remain issues. Here, by performing comprehensive lipidomic characterization of serum samples from 89 asymptomatic COVID-19 patients and 178 healthy controls, we screened
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