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Merck
CN

10820

抑肽酶 来源于牛肺

lyophilized, ~80% (HPCE), crystalline (fine), white, ≥3500 U/mg

别名:

BPTI, 抑肽酶, 牛胰胰蛋白酶抑制剂, 胰蛋白酶抑制剂（碱性）

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关于此项目

经验公式（希尔记法）:
C284H432N84O79S7
化学文摘社编号:
9087-70-1
分子量:
6511.44
UNSPSC Code:
12352202
NACRES:
NA.26
EC Number:
232-994-9
MDL number:
MFCD00130541

主要文件

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产品名称

抑肽酶 来源于牛肺, lyophilized, ~80% (HPCE), crystalline (fine), white, ≥3500 U/mg

SMILES string

S1SCC2NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C5NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C9N(CCC9)C(=O)CNC(=O)C(NC(=O)C(NC(=O)C%11N(CCC%11)C(=O

InChI

1S/C284H432N84O79S7/c1-21-144(9)222-271(439)337-174(68-46-105-309-282(300)301)239(407)340-187(120-160-77-85-164(374)86-78-160)251(419)341-185(116-156-55-29-24-30-56-156)250(418)342-188(121-161-79-87-165(375)88-80-161)252(420)346-191(123-208(291)378)246(41

InChI key

ZPNFWUPYTFPOJU-UHFFFAOYSA-N

biological source

bovine lung

assay

~80% (HPCE)

form

crystalline (fine)

quality

lyophilized

specific activity

≥3500 U/mg

mol wt

~6,500

technique(s)

electrophoresis: suitable

color

white

solubility

phosphate buffer: 5 mg/mL, clear, colorless (PH 7.6 (70 mm phosphate))

UniProt accession no.

P00974

storage temp.

2-8°C

Quality Level

200

Gene Information

cow ... PTI(404172)

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Application

抑肽酶被大量用作胰蛋白酶抑制剂。

Biochem/physiol Actions

抑肽酶是一种竞争性丝氨酸蛋白酶抑制剂，可与酶的活性位点组成稳定的复合酶并同时对其进行封闭。 这种结合是可逆的，而且绝大多数抑肽酶-蛋白酶复合物可在极端的pH >10 or < 3水平时发生解离。 从结构上来说，抑肽酶是一种来自牛肺的单体球状蛋白，由58个氨基酸组成并排列在具有三个交联二硫键的单个多肽链中。

Other Notes

一个胰蛋白酶抑制剂单位（TIU）可将两个胰蛋白酶单位的活性降低50％，而其中一个胰蛋白酶单位在pH 7.8和25℃下可每分钟水解1.0 μ摩尔的N-α-苯甲酰基-DL-精氨酸对硝基苯胺。另一种常用的单位是KIU，而1 TIU = 1,300 KIU。
1 U corresponds to 1 biological kallikrein inhibitor unit (KIU)

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

动植物源性产品
低风险生物材料
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN4261
BCCN4260
BCCJ6363
BCCJ6362
BCCG9260

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