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安全信息

10385

Sigma-Aldrich

Angiotensin III trifluoroacetate salt hydrate

≥98% (HPCE)

别名:

Des-Asp-1-Angiotensin II trifluoroacetate salt hydrate

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About This Item

经验公式（希尔记法）:
C46H66N12O9 · xC2HF3O2 · yH2O
CAS号:
12687-51-3
分子量:
931.09 (anhydrous free base basis)
Beilstein:
8385695
MDL编号:
MFCD20264812
UNSPSC代码:
12352200
PubChem化学物质编号:
57646800
NACRES:
NA.77

质量水平

100

方案

≥98% (HPCE)

溶解性

H2O: 1.0 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

O.OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O

InChI

1S/C46H66N12O9.C2HF3O2.H2O/c1-5-27(4)38(57-40(61)33(21-29-15-17-31(59)18-16-29)53-42(63)37(26(2)3)56-39(60)32(47)13-9-19-51-46(48)49)43(64)54-34(23-30-24-50-25-52-30)44(65)58-20-10-14-36(58)41(62)55-35(45(66)67)22-28-11-7-6-8-12-28;3-2(4,5)1(6)7;/h6-8,11-12,15-18,24-27,32-38,59H,5,9-10,13-14,19-23,47H2,1-4H3,(H,50,52)(H,53,63)(H,54,64)(H,55,62)(H,56,60)(H,57,61)(H,66,67)(H4,48,49,51);(H,6,7);1H2/t27-,32-,33-,34-,35-,36-,37-,38-;;/m0../s1

InChI key

JEOAJMGVSAMVML-UFPGTABSSA-N

Amino Acid Sequence

Arg-Val-Tyr-Ile-His-Pro-Phe

一般描述

Angiotensin III (Ang III) is a 7-AA bioactive peptide that is formed from the degradation of the Angiotensin II peptide by aminopeptidase A; both are derivatives of angiotensinogen and are components of the renin-angiotensin system (RAS).

生化/生理作用

Angiotensin III is an AT1 and AT2 agonist, with higher sensitivity for the AT2 receptor. Ang III has been shown to be a main effector peptide in RAS-controlled vasopresin release and a stimulator for aldosterone release.

特点和优势

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

抗体吸附剂

Arg-Val-Tyr-Ile-His-Pro-Phe-OH.3CH3COOH.4H2O

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCK4410
BCCK2388
BCCG8894
BCCG0845
BCCF6485

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Kamila Domińska et al.
Endokrynologia Polska, 60(5), 363-369 (2009-11-04)
The results of many studies have reported that peptides from the angiotensin family are involved in the regulation of cell growth, proliferation, cell migration, apoptosis, inflammation, differentiation, and angiogenesis, which suggests that they might play an important role in carcinogenesis.
Kenji Oki et al.
Endocrinology, 154(1), 214-221 (2012-12-12)
Aldosterone is synthesized in the zona glomerulosa of the adrenal cortex under primary regulation by the renin-angiotensin system. Angiotensin II (A-II) acts through the angiotensin types 1 and 2 receptors (AT1R and AT2R). A-II is metabolized in different tissues by
Rui Yang et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 34(6), 674-683 (2011-03-18)
Angiotensin (Ang) II, the main effector peptide of the renin-Ang system, increases arterial blood pressure through Ang II type 1A (AT(1a)) receptor-dependent arterial vasoconstriction and by decreasing renal salt and water excretion through extrarenal and intrarenal mechanisms. AT(2) receptors are
Brandon A Kemp et al.
Hypertension (Dallas, Tex. : 1979), 60(2), 387-395 (2012-06-13)
In angiotensin type 1 receptor-blocked rats, renal interstitial (RI) administration of des-aspartyl(1)-angiotensin II (Ang III) but not angiotensin II induces natriuresis via activation of angiotensin type 2 receptors. In the present study, renal function was documented during systemic angiotensin type
[Angiotensin I, angiotensin II, angiotensin III].
Chigusa Nakamura et al.
Nihon rinsho. Japanese journal of clinical medicine, 68 Suppl 7, 608-610 (2010-10-22)
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