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Merck
CN

07188

莫匹罗星锂

≥95.0% (HPLC)

别名:

9-((E)-4-{(2S,3R,4R,5S)-3,4-二羟基-5-[(2S,3S)-3-((1S,2S)-2-羟基-1-甲基-丙基)环氧乙烷基甲基]四氢吡喃-2-基}-3-甲基-丁-2-烯酰氧基)壬酸 锂盐, 假单胞菌酸A 锂盐

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关于此项目

经验公式(希尔记法):
C26H43LiO9
化学文摘社编号:
分子量:
506.56
UNSPSC Code:
51102829
PubChem Substance ID:
NACRES:
NA.85
MDL number:
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InChI key

XFIKMPRBSORKQP-JATHGWPISA-M

InChI

1S/C26H44O9.Li/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27;/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29);/q;+1/p-1/b16-13+;/t17-,18-,19-,20-,21-,24+,25-,26-;/m0./s1

assay

≥95.0% (HPLC)

form

powder

color

white to off-white

antibiotic activity spectrum

Gram-positive bacteria

mode of action

protein synthesis | interferes

Quality Level

Application

莫匹罗星锂已用于研究金黄色葡萄球菌和支原体敏感性研究中的莫匹罗星耐药性

Packaging

无底玻璃瓶。内含物装在锥底内插管中。

Other Notes

保存于密闭容器内,置于干燥通风处。置于干燥处保存。储存类别(TRGS 510):不可燃的固体

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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J Gilbart et al.
Antimicrobial agents and chemotherapy, 37(1), 32-38 (1993-01-01)
Mupirocin resistance in Staphylococcus aureus results from changes in the target enzyme, isoleucyl-tRNA synthetase (IRS). Twelve strains of S. aureus comprising four susceptible (MICs < or = 4 micrograms/ml), four intermediate level-resistant (MICs between 8 and 256 micrograms/ml), and four
P C Hannan
Journal of medical microbiology, 47(12), 1115-1122 (1998-12-18)
The susceptibilities of 40 strains of various Mycoplasma species to 10 classes of antimicrobial agents were compared in vitro by a broth microdilution method. The strains tested comprised 20 strains of four AIDS-associated species--M. penetrans (1 strain), M. fermentas (5
Victoria J Ryder et al.
PloS one, 7(10), e47695-e47695 (2012-10-31)
To investigate the development of mutational resistance to antibiotics in staphylococcal biofilms. Mutation frequencies to resistance against mupirocin and rifampicin were determined for planktonic cultures and for biofilms generated using either a novel static biofilm model or by continuous flow.
Yi-Yuan Chiu et al.
BMC genomics, 13 Suppl 7, S21-S21 (2013-01-11)
To discover a compound inhibiting multiple proteins (i.e. polypharmacological targets) is a new paradigm for the complex diseases (e.g. cancers and diabetes). In general, the polypharmacological proteins often share similar local binding environments and motifs. As the exponential growth of
Tomás García-Lozano et al.
Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 25(4), 252-255 (2013-01-11)
Our objective was to determine the prevalence of methicillin-resistant Staphylococcus aureus in workers who had direct contact with oncologic patients infected with MRSA and admitted to the intensive care unit of the Valencian Institute of Oncology. A study of prevalence

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