推荐产品
质量水平
方案
≥98.0%
98.0-102.0% (T)
SMILES字符串
OC(=O)c1ccnc(c1)C(O)=O
OC(=O)c1ccnc(c1)C(O)=O
InChI
1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
InChI key
MJIVRKPEXXHNJT-UHFFFAOYSA-N
应用
2,4-吡啶二羧酸是一种体外和细胞内抑制剂，也是组蛋白赖氨酸脱甲基酶的一种已知抑制剂。2,4-吡啶二甲酸已被用于一项研究中，以确定钌（II）配合物在体外对几种肿瘤细胞系具有抗转移作用，并且主要通过对细胞粘附、迁移和血管生成的影响来实现的。2,4-吡啶二甲酸已被用于开发一种检测方法，首次报道针对表观遗传学靶标的RapidFire质谱分析。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Nevenka Gligorijević et al.
Journal of inorganic biochemistry, 108, 53-61 (2012-01-24)
In our previous study, ruthenium(II)-p-cymene complexes of general formula [(η(6)-p-cymene)Ru(L)Cl2], L: 3-acetylpyridine (1), 2-amino-5-chloropyridine (2); and [(η(6)-p-cymene)Ru(HL)Cl], HL: 2,3-pyridinedicarboxylic acid (3), 2,4-pyridinedicarboxylic acid (4), revealed low antiproliferative activity, except complex [(η(6)-p-cymene)RuCl(picolinic acid)]·H(2)O (5) which exhibited IC(50) around 80 μM. In
H M Hanauske-Abel
Journal of hepatology, 13 Suppl 3, S8-15 (1991-01-01)
The hydrophilic compound pyridine 2,4-dicarboxylate (2,4-PDCA), designed as a mechanism-based competitive inhibitor of prolyl 4-hydroxylase, is efficiently excluded by the cytoplasmic membrane, but permeates the endoplasmic membrane via a 2,4-PDCA-selective translocator to reach its target enzyme in the intracisternal space.
Gunnar Schley et al.
The American journal of pathology, 181(5), 1595-1606 (2012-09-05)
The role of proximal versus distal tubular injury in the pathogenesis of acute kidney injury (AKI) is debatable. Inhibition of prolyl hydroxylases that regulate the degradation of hypoxia-inducible transcription factors (HIFs) is a promising therapeutic approach to optimize energy preservation
M Kristian Koski et al.
The Journal of biological chemistry, 282(51), 37112-37123 (2007-10-18)
Prolyl 4-hydroxylases (P4Hs) are 2-oxoglutarate dioxygenases that catalyze the hydroxylation of peptidyl prolines. They play an important role in collagen synthesis, oxygen homeostasis, and plant cell wall formation. We describe four structures of a P4H from the green alga Chlamydomonas
Florina Vlad et al.
Physiologia plantarum, 140(2), 199-207 (2010-06-18)
Prolyl 4-hydroxylases (P4Hs) catalyze the proline hydroxylation, a major post-translational modification, of hydroxyproline-rich glycoproteins. Two carnation petal P4H cDNAs, (Dianthus caryophyllus prolyl 4-hydroxylase) DcP4H1 and DcP4H2, were identified and characterized at the gene expression and biochemical level in order to
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